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Alterations in the metabolic and cardiorespiratory response to exercise in Huntington's Disease

Steventon, Jessica, Collett, J., Furby, Hannah, Hamana, Katy, Foster, Catherine, O'Callaghan, P., Dennis, A., Armstrong, R., Németh, A.H., Rosser, Anne Elizabeth, Murphy, Kevin, Quinn, Lori, Busse, Monica and Dawes, H. 2018. Alterations in the metabolic and cardiorespiratory response to exercise in Huntington's Disease. Parkinsonism and Related Disorders 54 , pp. 56-61. 10.1016/j.parkreldis.2018.04.014

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Abstract

Background Limited data suggests that an altered metabolic and cardiorespiratory exercise response may affect exercise performance in individuals with Huntington's disease (HD). There is no clear exploration of the response in individuals at different stages of the disease or in relation to genetic markers. This study aimed to examine the exercise response and recovery of HD participants, and the relationship to genetic and clinical markers. Method HD gene-positive participants (n = 31; 9 pre-manifest; 22 manifest HD) and a healthy control group (n = 29) performed an incremental exercise test until exhaustion. Performance, cardiorespiratory, metabolic and perceptual responses to exercise were determined from a maximal cycle ergometer test throughout the exercise test and during a recovery period. Results During sub-maximal exercise, metabolic (lactate levels, oxygen uptake) and cardiorespiratory markers (heart rate) were elevated in HD participants compared to controls. Lactate elevation was specific to pre-manifest HD participants. Work capacity was reduced in both pre-manifest and manifest HD participants with tests terminated with no difference in metabolic, perceptual or cardiorespiratory markers. Submaximal oxygen uptake was correlated with motor score, whilst peak measures were unrelated to genetic or clinical markers. Heart rate recovery was attenuated in pre-manifest and manifest HD participants. Conclusions Our findings confirm metabolic and cardiorespiratory deficits reduce exercise performance and affect recovery from an early stage in HD, with submaximal deficits related to phenotypic expression. Exercise capacity appears to be limited by an altered movement economy, thus clinicians should consider an altered exercise response and recovery may affect prescription in HD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Centre for Trials Research (CNTRR)
Cardiff University Brain Research Imaging Centre (CUBRIC)
Medicine
Physics and Astronomy
Psychology
Publisher: Elsevier
ISSN: 1353-8020
Date of First Compliant Deposit: 14 May 2018
Date of Acceptance: 12 April 2018
Last Modified: 22 Oct 2019 09:00
URI: http://orca.cf.ac.uk/id/eprint/111417

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