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Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol

Bisogno, Tiziana, Burston, James J., Rai, Ravi, Allarà, Marco, Saha, Bijali, Mahadevan, Anu, Razdan, Raj K., Wiley, Jenny L. and Di Marzo, Vincenzo 2009. Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. ChemMedChem 4 (6) , pp. 946-950. 10.1002/cmdc.200800442

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Abstract

Biosynthesis Inhibition: O‐5596, a new inhibitor of the biosynthesis of the endocannabinoid, 2‐arachidonoylglycerol, was synthesized and found to be potent (IC50=100 nM) and selective versus other proteins and enzymes of the endocannabinoid system in vitro and active in vivo at reducing food intake in mice.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Wiley-VCH Verlag
ISSN: 1860-7179
Last Modified: 11 Jul 2018 12:30
URI: http://orca.cf.ac.uk/id/eprint/112081

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