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Transcriptional profiling technology for studying vaccine responses: An untapped goldmine

Flanagan, K.L., Noho-Konteh, F., Ghazal, Peter and Dickinson, P. 2013. Transcriptional profiling technology for studying vaccine responses: An untapped goldmine. Methods 60 (3) , pp. 269-274. 10.1016/j.ymeth.2013.03.032

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Abstract

There is much that we do not understand about the immune mechanisms whereby vaccines exert their specific and non-specific effects. Most studies take the reductionist approach of examining vaccine responses at the humoral or cellular level. Whole human transcriptional profiling is becoming more accessible, and provides a picture of the entire immune response to vaccination in a single ‘snapshot’. The potential uses of such information are enormous, and the data mining tools are becoming more sophisticated to handle the complex data generated. We now face the exciting prospect of gaining in depth knowledge as to exactly what vaccines do to the immune system as a whole, and identifying molecular signatures and biomarkers that can predict immediate and long term outcomes of vaccination. The challenge now is to carry out the studies and generate the much needed data.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 1046-2023
Last Modified: 10 Jul 2018 12:00
URI: http://orca.cf.ac.uk/id/eprint/112264

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