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Global epidemiology of hyperthyroidism and hypothyroidism

Taylor, Peter N., Albrecht, Diana, Scholz, Anna, Gutierrez-Buey, Gala, Lazarus, John H., Dayan, Colin M. and Okosieme, Onyebuchi E. 2018. Global epidemiology of hyperthyroidism and hypothyroidism. Nature Reviews Endocrinology 14 (5) , pp. 301-316. 10.1038/nrendo.2018.18

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Abstract

Thyroid hormones are essential for growth, neuronal development, reproduction and regulation of energy metabolism. Hypothyroidism and hyperthyroidism are common conditions with potentially devastating health consequences that affect all populations worldwide. Iodine nutrition is a key determinant of thyroid disease risk; however, other factors, such as ageing, smoking status, genetic susceptibility, ethnicity, endocrine disruptors and the advent of novel therapeutics, including immune checkpoint inhibitors, also influence thyroid disease epidemiology. In the developed world, the prevalence of undiagnosed thyroid disease is likely falling owing to widespread thyroid function testing and relatively low thresholds for treatment initiation. However, continued vigilance against iodine deficiency remains essential in developed countries, particularly in Europe. In this report, we review the global incidence and prevalence of hyperthyroidism and hypothyroidism, highlighting geographical differences and the effect of environmental factors, such as iodine supplementation, on these data. We also highlight the pressing need for detailed epidemiological surveys of thyroid dysfunction and iodine status in developing countries.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Nature Publishing Group
ISSN: 1759-5029
Date of First Compliant Deposit: 10 July 2018
Last Modified: 18 Oct 2019 03:34
URI: http://orca.cf.ac.uk/id/eprint/112564

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