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Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions

Henderson, Scott H., West, Ryan A., Ward, Simon E. and Honey, Mark A. 2018. Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions. Royal Society Open Science 5 (6) , 180333. 10.1098/rsos.180333

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Abstract

The halodecarboxylation of heteroarene carboxylic acids by treatment with N-bromosuccinimide or N-chlorosuccinimide was performed. This procedure provides a convenient route to synthetically useful mono-halogenated heteroarene intermediates such as halo-indoles, -aza-indoles, -indazoles and -aza-indazoles. The mild conditions employed and simple protocol provides an advantage over traditional halodecarboxylation procedures that require expensive and toxic metal catalysts, basic conditions, time-consuming intermediate isolation and elevated reaction temperatures.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Medicine
Publisher: Royal Society, The
ISSN: 2054-5703
Date of First Compliant Deposit: 20 June 2018
Date of Acceptance: 10 April 2018
Last Modified: 21 Jun 2018 12:45
URI: http://orca.cf.ac.uk/id/eprint/112611

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