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Assessing the efficacy of cell transplantation for Parkinson's Disease: a patient-centered approach

Polgar, Stephen, Karimi, Leila, Buultjens, Melissa, Morris, Megan E. and Busse-Morris, Monica 2018. Assessing the efficacy of cell transplantation for Parkinson's Disease: a patient-centered approach. Journal of Parkinson's Disease 8 (3) , pp. 375-383. 10.3233/JPD-181309

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Background: Evidence from a growing number of preclinical studies indicate that recently discovered stem cell lines may be translated into viable cellular therapies for people with Parkinson’s disease. Objectives: In a brief but critical review, we examine the use of primary and secondary outcome measures currently used to evaluate the efficacy of cellular therapies. Methods: The current practice of relying on a single primary outcome measure does not appear to provide the evidence required for demonstrating the robust, life-changing recovery anticipated with the successful implementation of cellular therapies. Results: We propose a 360-degree assessment protocol, which includes co-primary and composite outcome measures to provide accurate and comprehensive evidence of treatment efficacy, from the perspectives of both the researchers and the patients.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: IOS Press
ISSN: 1877-7171
Date of First Compliant Deposit: 29 June 2018
Date of Acceptance: 17 April 2018
Last Modified: 03 Sep 2018 12:31

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