Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1

Foley, David W., Bermudez, Isabel, Bailey, Patrick D. and Meredith, David 2016. A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1. MedChemComm 7 (5) , pp. 999-1002. 10.1039/C5MD00575B

Full text not available from this repository.

Abstract

The mammalian proton-coupled oligopeptide transporter PepT1 is recognised as an important route of oral drug delivery. Peptide-based compounds offer great potential as drugs but their application is limited by poor membrane permeability, amongst other challenges. Using cyclosporin A as a proof-of-concept, we demonstrate for the first time that peptidic molecules over 1000 Da in size can be targeted towards and transported by PepT1.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: Royal Society of Chemistry
ISSN: 2040-2503
Date of Acceptance: 12 March 2016
Last Modified: 21 Sep 2018 09:22
URI: http://orca.cf.ac.uk/id/eprint/113074

Citation Data

Cited 1 time in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item