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Synchronized oscillations at alpha and theta frequencies in the lateral geniculate nucleus

Hughes, Stuart Wynn, Lörincz, Magor, Cope, David William, Blethyn, Kate L., Kékesi, Katalin A, Parri, H. Rheinallt, Juhász, Gabor and Crunelli, Vincenzo 2004. Synchronized oscillations at alpha and theta frequencies in the lateral geniculate nucleus. Neuron , pp. 253-268. 10.1016/S0896-6273(04)00191-6

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Abstract

In relaxed wakefulness, the EEG exhibits robust rhythms in the ? band (8–13 Hz), which decelerate to ? (2–7 Hz) frequencies during early sleep. In animal models, these rhythms occur coherently with synchronized activity in the thalamus. However, the mechanisms of this thalamic activity are unknown. Here we show that, in slices of the lateral geniculate nucleus maintained in vitro, activation of the metabotropic glutamate receptor (mGluR) mGluR1a induces synchronized oscillations at ? and ? frequencies that share similarities with thalamic ? and ? rhythms recorded in vivo. These in vitro oscillations are driven by an unusual form of burst firing that is present in a subset of thalamocortical neurons and are synchronized by gap junctions. We propose that mGluR1a-induced oscillations are a potential mechanism whereby the thalamus promotes EEG ? and ? rhythms in the intact brain.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
ISSN: 0896-6273
Last Modified: 08 May 2019 02:45
URI: http://orca.cf.ac.uk/id/eprint/1131

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