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The ticking CLOCK of HSV-2 pathology

Bayliss, Rebecca J. and Piguet, Vincent 2018. The ticking CLOCK of HSV-2 pathology. Journal of Investigative Dermatology 138 (1) , pp. 17-19. 10.1016/j.jid.2017.08.028

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Abstract

Herpes simplex virus type 2 (HSV-2) is the causative agent of genital herpes. Matsuzawa et al have demonstrated that, in a mouse model, HSV-2 pathology is influenced by the time infection occurs. Increased expression of the HSV-2 receptor Nectin-1 under the control of CLOCK coincided with an increase in viral titer suggesting that HSV-2 infection is regulated by the host circadian clock.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Nature Publishing Group
ISSN: 0022-202X
Date of First Compliant Deposit: 16 July 2018
Date of Acceptance: 20 November 2017
Last Modified: 27 Jun 2019 07:59
URI: http://orca.cf.ac.uk/id/eprint/113193

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