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Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation

Crunelli, Vincenzo, Gould, Timothy M. and Parri, Harri Rheinallt 2001. Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation. Nature Neuroscience , pp. 803-812. 10.1038/90507

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Abstract

Astrocytes respond to chemical, electrical and mechanical stimuli with transient increases in intracellular calcium concentration ([Ca2+]i). We now show that astrocytes in situ display intrinsic [Ca2+]i oscillations that are not driven by neuronal activity. These spontaneous astrocytic oscillations can propagate as waves to neighboring astrocytes and trigger slowly decaying NMDA receptor-mediated inward currents in neurons located along the wave path. These findings show that astrocytes in situ can act as a primary source for generating neuronal activity in the mammalian central nervous system.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
ISSN: 1097-6256
Last Modified: 15 Dec 2017 08:35
URI: http://orca.cf.ac.uk/id/eprint/1132

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