Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Cell interaction microarray for blood phenotyping

Campbell, Colin J., O'Looney, Nichola, Chong Kwan, Marisa, Robb, Janine S., Ross, Alan J., Beattie, John S., Petrik, Juraj and Ghazal, Peter 2006. Cell interaction microarray for blood phenotyping. Analytical Chemistry 78 (6) , pp. 1930-1938. 10.1021/ac051651m

Full text not available from this repository.

Abstract

Microarrays promise great advances in areas of diagnostic testing where there is a need to perform multiple assays in parallel. In the short term, protein microarrays have a greater potential to impact diagnostics than DNA arrays due to their potential for direct sample measurements. Here, we report an antibody microarray technique for selectively recognizing glycan and peptide motifs on the surface of red blood cells. We present results demonstrating the optimization and efficacy of the microarray approach as a highly sensitive and specific microscale multiplex assay for blood typing. We also show that our microarray can be used to screen red blood cell surface antigens using whole blood in a label-free detection mode. Finally, our results indicate this method has potential for broader applications in biochip medicine

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: American Chemical Society
ISSN: 0003-2700
Date of Acceptance: 30 December 2005
Last Modified: 25 Jul 2018 10:15
URI: http://orca.cf.ac.uk/id/eprint/113402

Citation Data

Cited 24 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item