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Redox pathways as drug targets in microaerophilic parasites

Leitsch, David, Williams, Catrin F. and Hrdy, Ivan 2018. Redox pathways as drug targets in microaerophilic parasites. Trends in Parasitology 34 (7) , pp. 576-589. 10.1016/j.pt.2018.04.007

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Abstract

The microaerophilic parasites Entamoeba histolytica, Trichomonas vaginalis, and Giardia lamblia jointly cause hundreds of millions of infections in humans every year. Other microaerophilic parasites such as Tritrichomonas foetus and Spironucleus spp. pose a relevant health problem in veterinary medicine. Unfortunately, vaccines against these pathogens are unavailable, but their microaerophilic lifestyle opens opportunities for specifically developed chemotherapeutics. In particular, their high sensitivity towards oxygen can be exploited by targeting redox enzymes. This review focusses on the redox pathways of microaerophilic parasites and on drugs, either already in use or currently in the state of development, which target these pathways.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Engineering
Subjects: Q Science > QR Microbiology
Publisher: Elsevier
ISSN: 1471-4922
Funders: International Glaucoma Association, Ser Cymru II Fellowship part-funded by the European regional Development Fund through the Welsh Government., NPU II (LQ1604) provided by the Ministry of Education, Youth and Sport of the Czech Republic, project BIOCEV (CZ.1.05/1.1.00/02.0109) and project CePaViP (CZ.02.1.01/ 0.0/0.0/16_019/0000759) supported by ERD Funds.
Last Modified: 22 Jul 2019 12:53
URI: http://orca.cf.ac.uk/id/eprint/113560

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