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cAMP Responsive Element-Binding Protein Phosphorylation Is Necessary for Perirhinal Long-Term Potentiation and Recognition Memory

Warburton, E. C., Glover, C. P. J., Massey, P. V., Wan, H., Johnson, B., Bienemann, A., Deuschle, U., Kew, J. N. C., Aggleton, John Patrick, Bashir, Z. I., Uney, J. and Brown, M. W. 2005. cAMP Responsive Element-Binding Protein Phosphorylation Is Necessary for Perirhinal Long-Term Potentiation and Recognition Memory. The Journal of Neuroscience 25 (27) , pp. 6296-6303. 10.1523/JNEUROSCI.0506-05.2005

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We established the importance of phosphorylation of cAMP responsive element-binding protein (CREB) to both the familiarity discrimination component of long-term recognition memory and plasticity within the perirhinal cortex of the temporal lobe. Adenoviral transduction of perirhinal cortex (and adjacent visual association cortex) with a dominant-negative inhibitor of CREB impaired the preferential exploration of novel over familiar objects at a long (24 h) but not a short (15 min) delay, disrupted the normal reduced activation of perirhinal neurons to familiar compared with novel pictures, and impaired long-term potentiation of synaptic transmission in perirhinal slices. The consistency of these effects across the behavioral, systems, and cellular levels of analysis provides strong evidence for involvement of CREB phosphorylation in synaptic plastic processes within perirhinal cortex necessary for long-term recognition memory.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: temporal lobe; plasticity; familiarity discrimination; viral transduction; hippocampus; Fos
Additional Information: Pdf uploaded in accordance with publisher's policy at (accessed 27/02/2014).
Publisher: Society for Neuroscience
ISSN: 0270-6474
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 02:42

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