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Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells.

Ghazal, P., DeMattei, C., Giulietti, E., Kliewer, S. A., Umesono, K. and Evans, R. M. 1992. Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells. Proceedings of the National Academy of Sciences 89 (16) , pp. 7630-7634. 10.1073/pnas.89.16.7630

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Abstract

Reactivation of latent virus is believed to result from a signal transduction event that induces immediate-early (IE) gene transcription. Evidence is presented that the major IE promoter (MIEP) of human cytomegalovirus (hCMV) is activated by physiological levels of retinoic acid (RA) in human embryonal carcinoma cells. Mutagenesis experiments localized in the MIEP enhancer, a retinoic acid-responsive element composed of a direct repeat separated by five nucleotides. Protein-DNA binding experiments revealed that this element functions as a specific target site for the direct interaction of nuclear receptor proteins for RA. These findings implicate the biologically active derivative of vitamin A (RA) as a potential modulator of hCMV pathogenesis in infants and immunocompromised adults.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: National Academy of Sciences
ISSN: 0027-8424
Last Modified: 31 Jul 2018 09:30
URI: http://orca.cf.ac.uk/id/eprint/113742

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