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Benzodiazepine impairment of perirhinal cortical plasticity and recognition memory

Wan, H., Warburton, E. C., Zhu, X. O., Koder, T. J., Park, Y., Aggleton, John Patrick, Cho, K., Bashir, Z. I. and Brown, M. W. 2004. Benzodiazepine impairment of perirhinal cortical plasticity and recognition memory. European Journal of Neuroscience 20 (8) , pp. 2214-2224. 10.1111/j.1460-9568.2004.03688.x

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Benzodiazepines, including lorazepam, are widely used in human medicine as anxiolytics or sedatives, and at higher doses can produce amnesia. Here we demonstrate that in rats lorazepam impairs both recognition memory and synaptic plastic processes (long-term depression and long-term potentiation). Both impairments are produced by actions in perirhinal cortex. The findings thus establish a mechanism by means of which benzodiazepines impair recognition memory. The findings also strengthen the hypotheses that the familiarity discrimination component of recognition memory is dependent on reductions in perirhinal neuronal responses when stimuli are repeated and that these response reductions are due to a plastic mechanism also used in long-term depression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: amnesia; GABA; lorazepam; LTP and LTD; rat
Publisher: Wiley-Blackwell
ISSN: 0953-816X
Last Modified: 04 Jun 2017 02:42

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