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Measures of cardiac function in Theraphosidae spiders using in vivo magnetic resonance imaging

Merrifield, Gavin D., Brydges, Nichola, Hall, Lynsey, Mullin, James, Gallagher, Lindsay, Pizzi, Romain and Holmes, William 2018. Measures of cardiac function in Theraphosidae spiders using in vivo magnetic resonance imaging. Physiological Entomology 43 (3) , pp. 207-213. 10.1111/phen.12245

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Abstract

We report the first in vivo cardiac magnetic resonance imaging (MRI) measurements of Theraphosidae spiders. MRI scanning is performed on six spiders under isoflurane‐induced anaesthesia. Retrospective self‐gating cine‐cardiac MRI (RG‐CINE‐MRI) is used to overcome the difficulties of prospective cardiac gating in this species. The resulting RG‐CINE‐MRI images are successfully analyzed to obtain functional cardiac parameters from live spiders at rest. Cardiac ejection fraction is found to increase with animal mass (Pearson correlation 0.849, P = 0.03) at a faster rate than myocardial tissue volume, whereas heart rate remains constant across animals. This suggests the spider heart undergoes additional biomechanical loading with age. The results of the present study demonstrate the potential for retrospective gating with respect to evaluating aspects of cardiac function in a wide range of previously inaccessible species.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Wiley-Blackwell
ISSN: 0307-6962
Date of Acceptance: 1 May 2018
Last Modified: 18 Oct 2018 13:40
URI: http://orca.cf.ac.uk/id/eprint/113798

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