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Lesions of the mammillothalamic tract impair the acquisition of spatial but not nonspatial contextual conditional discriminations

Vann, Seralynne Denise, Honey, Robert Colin and Aggleton, John Patrick 2003. Lesions of the mammillothalamic tract impair the acquisition of spatial but not nonspatial contextual conditional discriminations. European Journal of Neuroscience 18 (8) , pp. 2413-2416. 10.1046/j.1460-9568.2003.02959.x

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Abstract

This study examined the influence of selective mammillothalamic tract lesions in rats on the acquisition of two kinds of contextual conditional discrimination: one involving two contexts (A and B) that differed in their visuo-spatial properties and another involving two contexts (C and D) that differed in temperature. In contexts A (and C) presentations of a tone were paired with food whereas presentations of a clicker were not; and in contexts B (and D) presentations of the clicker were paired with food whereas those of the tone were not. Mammillothalamic tract lesions disrupted initial acquisition of the conditional discrimination involving visual contexts (A and B), but not the formally equivalent discrimination involving thermal contexts (C and D). These results provide support for the suggestion that mammillothalamic tract lesions disrupt visuo-spatial encoding.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: contextual conditional discriminations; mammillothalamic tract; nonspatial; rat; spatial
Publisher: Wiley-Blackwell
ISSN: 0953-816X
Last Modified: 04 Jun 2017 02:42
URI: http://orca.cf.ac.uk/id/eprint/11383

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