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Genomic imprinting and neurobehavioral programming by adverse early life environments: evidence from studying Cdkn1c

Isles, Anthony R. and John, Rosalind M. 2019. Genomic imprinting and neurobehavioral programming by adverse early life environments: evidence from studying Cdkn1c. Current Opinion in Behavioral Sciences 25 , pp. 31-35. 10.1016/j.cobeha.2018.06.008

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Abstract

Imprinted genes are subject to epigenetic regulation that leads to monoallelic expression from one parental allele only. Brain expression of the imprinted gene Cdkn1c is sensitive to early life adversity, including exposure to maternal low protein diet (LPD) where increased expression of Cdkn1c is due to de-repression of the normally silent paternal allele. Maternal LPD also leads to changes in the dopamine system and reward related behaviours in offspring. We have recently demonstrated that these brain and behavioural phenotypes are recapitulated in a transgenic model in which Cdkn1c expressi alone is increased. Here we summarise these findings and suggest that the loss of imprinting of Cdkn1c in the offspring following maternal low protein diet is a key contributor to the associated changes in the dopamine system and behavior reported after early life adversity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Publisher: Elsevier
ISSN: 2352-1546
Date of First Compliant Deposit: 3 August 2018
Date of Acceptance: 5 June 2018
Last Modified: 19 Oct 2019 19:02
URI: http://orca.cf.ac.uk/id/eprint/113880

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