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Neurotoxic lesions of the rat perirhinal cortex fail to disrupt the acquisition of performance of tests of allocentric spatial memory

Machin, P., Vann, Seralynne Denise, Muir, Janice L. and Aggleton, John Patrick 2002. Neurotoxic lesions of the rat perirhinal cortex fail to disrupt the acquisition of performance of tests of allocentric spatial memory. Behavioral Neuroscience 116 (2) , pp. 232-240. 10.1037//0735-7044.116.2.232

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Abstract

Rats with neurotoxic lesions of the perirhinal cortex (n = 9) were compared with sham controls (n = 14) on a working memory task in the radial am maze. Rats were trained under varying levels of proactive interference and with different retention intervals. Finally, performance was assessed when the maze was switched to a novel room. None of these manipulations differentially impaired rats with perirhinal lesions. Rats were next trained on delayed matching-to-place in the water maze. Even with retention delays of 30 min, there was no evidence of a deficit. Although interactions between the perirhinal cortex and hippocampus may be important for integrating object-place information, the perirhinal cortex is often not necessary for tasks that selectively tax allocentric spatial memory.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: American Psychological Association
ISSN: 0735-7044
Last Modified: 04 Jun 2017 02:42
URI: http://orca.cf.ac.uk/id/eprint/11392

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Cited 18 times in Web of Science. View in Web of Science.

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