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Cell-specific activity of the modulator region in the human cytomegalovirus major immediate-early gene

Lubon, H, Ghazal, Peter, Hennighausen, L, Reynolds-Kohler, C, Lockshin, C and Nelson, J 1989. Cell-specific activity of the modulator region in the human cytomegalovirus major immediate-early gene. Molecular and Cellular Biology 9 (3) , pp. 1342-1345. 10.1128/MCB.9.3.1342

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Abstract

In this paper we demonstrate that modulator sequences upstream of the enhancer of the major immediate-early promoter of human cytomegalovirus exert a differential effect on the level of transcription in a variety of cells and that this region has the capacity to interact with specific nuclear protein. Depending on the cell type, these modulator sequences increased or decreased transcriptional activation from the IE1 gene promoter-enhancer. The cell lines identified in this report should be useful to study the molecular mechanism of cell-specific transcriptional repression and activation exerted by the major immediate-early promoter upstream region.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: American Society for Microbiology
ISSN: 0270-7306
Date of Acceptance: 9 November 1988
Last Modified: 07 Sep 2018 12:30
URI: http://orca.cf.ac.uk/id/eprint/114065

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