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Multiple sequence-specific transcription factors modulate cytomegalovirus enhancer activity in vitro

Ghazal, Peter, Lubon, Henryk and Hennighausen, Lothar 1988. Multiple sequence-specific transcription factors modulate cytomegalovirus enhancer activity in vitro. Molecular and Cellular Biology 8 (4) , pp. 1809-1811. 10.1128/MCB.8.4.1809

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Abstract

The possibility of DNA-binding proteins interacting in vitro with the polymerase II transcriptional machinery was explored by using a competition assay with individual target sequences for enhancer-binding factors. Transcription factors binding to at least five specific enhancer sequences mediate the activity of the human cytomegalovirus immediate-early 1 gene in vitro. Furthermore, our data suggest that individual DNA-bound enhancer factors can interact with the promoter transcription complex.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: American Society for Microbiology
ISSN: 0270-7306
Date of Acceptance: 5 January 1988
Last Modified: 07 Sep 2018 11:15
URI: https://orca.cardiff.ac.uk/id/eprint/114068

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