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LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics

Fahy, Eoin, Alvarez-Jarreta, Jorge, Brasher, Christopher, Nguyen, An, Hawksworth, Jade, Rodrigues, Patricia, Meckelmann, Sven, Allen, Stuart and O'Donnell, Valerie 2018. LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics. Bioinformatics 35 (4) , pp. 685-687. 10.1093/bioinformatics/bty679

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Abstract

Summary We present LipidFinder online, hosted on the LIPID MAPS website, as a liquid chromatography/mass spectrometry (LC/MS) workflow comprising peak filtering, MS searching and statistical analysis components, highly customized for interrogating lipidomic data. The online interface of LipidFinder includes several innovations such as comprehensive parameter tuning, a MS search engine employing in-house customized, curated and computationally generated databases and multiple reporting/display options. A set of integrated statistical analysis tools which enable users to identify those features which are significantly-altered under the selected experimental conditions, thereby greatly reducing the complexity of the peaklist prior to MS searching is included. LipidFinder is presented as a highly flexible, extensible user-friendly online workflow which leverages the lipidomics knowledge base and resources of the LIPID MAPS website, long recognized as a leading global lipidomics portal.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Computer Science & Informatics
Medicine
Publisher: Oxford University Press (OUP): Policy B - Oxford Open Option B
ISSN: 1367-4803
Funders: Wellcome Trust
Date of First Compliant Deposit: 3 September 2018
Date of Acceptance: 6 August 2018
Last Modified: 12 Jun 2019 02:14
URI: http://orca.cf.ac.uk/id/eprint/114547

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