%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Micaela Gal, Nicholas A. Francis, Kerenza Hood, Jorge Villacian, Herman Goossens, Angela Watkins, Christopher C. Butler, the RAPP-ID consortium
Matching diagnostics development to clinical need: Target product profile development for a point of care test for community-acquired lower respiratory tract infection
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 12 0 R/Contents 13 0 R/TrimBox[0 0 612 792]>>
endobj
12 0 obj
[14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R]
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref001)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref002)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref003)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref004)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref005)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref006)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref007)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref008)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref009)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref010)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref011)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref012)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref013)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref014)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref015)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref016)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref017)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref018)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.ref019)>>
endobj
33 0 obj
<>/Border[0 0 0]/A 34 0 R>>
endobj
34 0 obj
<>
endobj
13 0 obj
[35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R]
endobj
35 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 567.6143 m
199.9998 567.6143 l
199.9998 568.1143 l
575.9997 568.1143 l
f*
0.83 0.64 0.02 0 k
305.0646 458.9291 m
309.8835 458.9291 l
h
f*
314.4756 458.9291 m
319.2945 458.9291 l
h
f*
297.5244 380.9197 m
302.3433 380.9197 l
h
f*
313.9087 380.9197 m
318.7276 380.9197 l
h
f*
486.7087 367.937 m
491.5276 367.937 l
h
f*
503.0929 367.937 m
507.9118 367.937 l
h
f*
226.9417 328.9323 m
231.8173 328.9323 l
h
f*
243.326 328.9323 m
248.1449 328.9323 l
h
f*
259.7102 328.9323 m
264.5291 328.9323 l
h
f*
283.4079 250.9228 m
293.1024 250.9228 l
h
f*
304.611 250.9228 m
314.3055 250.9228 l
h
f*
337.0961 224.9008 m
346.7906 224.9008 l
h
f*
422.5323 198.9354 m
432.2268 198.9354 l
h
f*
441.411 198.9354 m
451.1055 198.9354 l
h
f*
460.2898 198.9354 m
469.9843 198.9354 l
h
f*
386.022 159.9307 m
395.7165 159.9307 l
h
f*
400.252 159.9307 m
409.9465 159.9307 l
h
f*
234.085 133.9087 m
243.7795 133.9087 l
h
f*
252.9638 133.9087 m
262.6583 133.9087 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(CA-LRTI)Tj
4.0818 0 Td
(POCT)Tj
2.9898 0 Td
(included)Tj
3.885 0 Td
(the)Tj
1.5993 0 Td
(use)Tj
1.8142 0 Td
(of)Tj
1.0443 0 Td
(minimally)Tj
4.3325 0 Td
(invasive)Tj
3.7895 0 Td
(samples,)Tj
4.1773 0 Td
(a)Tj
0.7699 0 Td
(result)Tj
2.6377 0 Td
(in)Tj
0.9846 0 Td
(less)Tj
1.9753 0 Td
(than)Tj
2.1424 0 Td
(30)Tj
1.3189 0 Td
(min-)Tj
-37.5425 -1.474 Td
(utes,)Tj
2.3572 0 Td
(no)Tj
1.3129 0 Td
(more)Tj
2.4706 0 Td
(than)Tj
2.1304 0 Td
(a)Tj
0.7639 0 Td
(single)Tj
2.7869 0 Td
(preparation)Tj
5.2038 0 Td
(step,)Tj
2.3572 0 Td
(minimum)Tj
4.2311 0 Td
(operational)Tj
5.0904 0 Td
(requirements,)Tj
6.26 0 Td
(and)Tj
1.862 0 Td
(detec-)Tj
-36.8264 -1.474 Td
(tion)Tj
1.8081 0 Td
(of)Tj
1.0444 0 Td
(common)Tj
4.0282 0 Td
(respiratory)Tj
4.8875 0 Td
(pathogens)Tj
4.8338 0 Td
(and)Tj
1.8678 0 Td
(their)Tj
2.1365 0 Td
(resistance)Tj
4.7263 0 Td
(to)Tj
1.0504 0 Td
(commonly)Tj
4.7323 0 Td
(prescribed)Tj
-31.1153 -1.474 Td
(antibiotics.)Tj
ET
Q
q
1 j
1 J
0 w
11.4998 0 0 11.4998 200.0125 626.1165 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusions)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 609.1086 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(This)Tj
2.0886 0 Td
(multidisciplinary)Tj
6.9643 0 Td
(,)Tj
0.4953 0 Td
(multistage)Tj
4.7264 0 Td
(partnership)Tj
5.162 0 Td
(approach)Tj
4.3385 0 Td
(generated)Tj
4.6667 0 Td
(a)Tj
0.7698 0 Td
(clinically-driven)Tj
6.8986 0 Td
(TPP)Tj
2.1544 0 Td
(for)Tj
-38.2646 -1.474 Td
(guiding)Tj
3.3896 0 Td
(the)Tj
1.5993 0 Td
(development)Tj
5.8782 0 Td
(of)Tj
1.0443 0 Td
(a)Tj
0.7698 0 Td
(new)Tj
2.035 0 Td
(POCT,)Tj
3.2643 0 Td
(and)Tj
1.8679 0 Td
(this)Tj
1.7545 0 Td
(approach)Tj
4.3384 0 Td
(as)Tj
1.2652 0 Td
(well)Tj
1.9156 0 Td
(as)Tj
1.2652 0 Td
(the)Tj
1.5933 0 Td
(TPP)Tj
2.1603 0 Td
(itself)Tj
2.2498 0 Td
(may)Tj
-36.3907 -1.474 Td
(be)Tj
1.3188 0 Td
(useful)Tj
2.8525 0 Td
(to)Tj
1.0444 0 Td
(others)Tj
2.9719 0 Td
(developing)Tj
4.9889 0 Td
(a)Tj
0.7639 0 Td
(new)Tj
2.035 0 Td
(POCT.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 502.9795 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 485.9716 cm
BT
/F6 1 Tf
1 TL
0.005 Tc
0 0 Td
(A)Tj
0.9127 0 Td
(primary)Tj
3.5149 0 Td
(care)Tj
1.9106 0 Td
(point)Tj
2.4037 0 Td
(of)Tj
1.0318 0 Td
(care)Tj
1.9106 0 Td
(test)Tj
1.6327 0 Td
(\(POCT\))Tj
3.5376 0 Td
(is)Tj
0.8674 0 Td
(a)Tj
0.6633 0 Td
(test)Tj
1.6328 0 Td
(carried)Tj
3.1011 0 Td
(out)Tj
1.5817 0 Td
(near)Tj
2.0353 0 Td
(to)Tj
1.0431 0 Td
(the)Tj
1.4967 0 Td
(patient)Tj
3.0671 0 Td
(that)Tj
1.8141 0 Td
(gener-)Tj
-34.1572 -1.2982 Td
(ates)Tj
1.7688 0 Td
(a)Tj
0.6633 0 Td
(result)Tj
2.5058 0 Td
(without)Tj
3.3902 0 Td
(reference)Tj
3.9968 0 Td
(to)Tj
1.0432 0 Td
(a)Tj
0.6633 0 Td
(laboratory,)Tj
4.6771 0 Td
(and)Tj
1.7575 0 Td
(rapidly)Tj
3.101 0 Td
(enough)Tj
3.2712 0 Td
(to)Tj
1.0431 0 Td
(affect)Tj
2.4322 0 Td
(patient)Tj
3.067 0 Td
(manage-)Tj
-33.3805 -1.2983 Td
(ment)Tj
2.347 0 Td
(at)Tj
0.9695 0 Td
(the)Tj
1.4966 0 Td
(point)Tj
2.4038 0 Td
(of)Tj
1.0318 0 Td
(care)Tj
1.9049 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2926 0 Td
(2)Tj
0 g
(].)Tj
1.2869 0 Td
(POCT)Tj
2.8346 0 Td
(development)Tj
5.5105 0 Td
(has)Tj
1.5704 0 Td
(often)Tj
2.3301 0 Td
(been)Tj
2.1543 0 Td
(driven)Tj
2.8687 0 Td
(by)Tj
1.2018 0 Td
(technological)Tj
-31.2035 -1.2982 Td
(innovation)Tj
4.6884 0 Td
(rather)Tj
2.6986 0 Td
(than)Tj
2.0693 0 Td
(in)Tj
1.0488 0 Td
(response)Tj
3.8097 0 Td
(to)Tj
1.0432 0 Td
(a)Tj
0.6633 0 Td
(clearly)Tj
2.8799 0 Td
(defined)Tj
3.2882 0 Td
(unmet)Tj
2.8857 0 Td
(clinical)Tj
3.1464 0 Td
(need,)Tj
2.4151 0 Td
(and)Tj
1.7575 0 Td
(as)Tj
1.0318 0 Td
(a)Tj
0.6633 0 Td
(conse-)Tj
-34.0892 -1.304 Td
(quence)Tj
3.1237 0 Td
(many)Tj
2.5172 0 Td
(POCTS)Tj
3.3165 0 Td
(have)Tj
2.0976 0 Td
(not)Tj
1.6044 0 Td
(been)Tj
2.1543 0 Td
(taken)Tj
2.4661 0 Td
(up)Tj
1.287 0 Td
(into)Tj
1.8765 0 Td
(routine)Tj
3.2258 0 Td
(clinical)Tj
3.1464 0 Td
(care.)Tj
2.143 0 Td
(There)Tj
2.6192 0 Td
(are)Tj
1.4797 0 Td
(also)Tj
1.8028 0 Td
(some)Tj
-34.8602 -1.2982 Td
(clinical)Tj
3.1464 0 Td
(niches)Tj
2.8233 0 Td
(where)Tj
2.6985 0 Td
(POCTs)Tj
3.2032 0 Td
(are)Tj
1.4796 0 Td
(urgently)Tj
3.6284 0 Td
(required.)Tj
3.9401 0 Td
(For)Tj
1.6554 0 Td
(example,)Tj
3.8495 0 Td
(there)Tj
2.3073 0 Td
(is)Tj
0.8674 0 Td
(a)Tj
0.6633 0 Td
(need)Tj
2.177 0 Td
(for)Tj
-32.4394 -1.2983 Td
(improved)Tj
4.1782 0 Td
(POCTs)Tj
3.2088 0 Td
(to)Tj
1.0431 0 Td
(help)Tj
1.9673 0 Td
(primary)Tj
3.5206 0 Td
(care)Tj
1.9048 0 Td
(clinicians)Tj
4.0989 0 Td
(to)Tj
1.0432 0 Td
(safely)Tj
2.4831 0 Td
(reduce)Tj
2.9707 0 Td
(and)Tj
1.7575 0 Td
(better)Tj
2.5965 0 Td
(target)Tj
2.5625 0 Td
(antibiotic)Tj
-33.3352 -1.3039 Td
(prescribing)Tj
4.8415 0 Td
(for)Tj
1.4116 0 Td
(common)Tj
3.9005 0 Td
(infections)Tj
4.2406 0 Td
(such)Tj
2.0976 0 Td
(as)Tj
1.0318 0 Td
(community)Tj
4.9663 0 Td
(acquired)Tj
3.7757 0 Td
(lower)Tj
2.4945 0 Td
(respiratory)Tj
4.6998 0 Td
(tract)Tj
-33.4599 -1.2983 Td
(infections)Tj
4.2406 0 Td
(\(CA-LRTIs\))Tj
5.159 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(],)Tj
1.6384 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
1.6384 0 Td
(CA-LRTIs)Tj
4.4617 0 Td
(are)Tj
1.474 0 Td
(one)Tj
1.7291 0 Td
(of)Tj
1.0318 0 Td
(the)Tj
1.4967 0 Td
(leading)Tj
3.1918 0 Td
(acute)Tj
2.3754 0 Td
(reasons)Tj
3.2882 0 Td
(for)Tj
1.4116 0 Td
(consulting)Tj
-33.1367 -1.2982 Td
(in)Tj
1.0544 0 Td
(primary)Tj
3.515 0 Td
(care,)Tj
2.1429 0 Td
(and)Tj
1.7575 0 Td
(20%-95%)Tj
4.0535 0 Td
(of)Tj
1.0318 0 Td
(patients)Tj
3.4356 0 Td
(are)Tj
1.4797 0 Td
(prescribed)Tj
4.5014 0 Td
(an)Tj
1.2189 0 Td
(antibiotic)Tj
4.1272 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(],)Tj
1.6384 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
1.6384 0 Td
(More)Tj
2.4491 0 Td
(than)Tj
-34.0438 -1.304 Td
(80%)Tj
1.9558 0 Td
(of)Tj
1.0318 0 Td
(these)Tj
2.2961 0 Td
(antibiotics)Tj
4.5014 0 Td
(may)Tj
1.9559 0 Td
(be)Tj
1.1678 0 Td
(unnecessary)Tj
5.1931 0 Td
(as)Tj
1.0318 0 Td
(CA-LRTIs)Tj
4.4617 0 Td
(in)Tj
1.0545 0 Td
(developed)Tj
4.354 0 Td
(countries)Tj
4.0308 0 Td
(are)Tj
1.474 0 Td
(largely)Tj
-34.5087 -1.2982 Td
(self-limiting)Tj
5.1816 0 Td
(and)Tj
1.7575 0 Td
(the)Tj
1.4967 0 Td
(majority)Tj
3.702 0 Td
(of)Tj
1.0318 0 Td
(patients)Tj
3.4413 0 Td
(do)Tj
1.2756 0 Td
(not)Tj
1.5987 0 Td
(benefit)Tj
3.0387 0 Td
(meaningfully)Tj
5.5956 0 Td
(from)Tj
2.245 0 Td
(antibiotic)Tj
4.1272 0 Td
(treat-)Tj
-34.4917 -1.2983 Td
(ment)Tj
2.347 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(],)Tj
1.6328 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(],)Tj
1.6384 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
1.6384 0 Td
(A)Tj
0.9127 0 Td
(rapid)Tj
2.3811 0 Td
(POCT)Tj
2.8347 0 Td
(that)Tj
1.8141 0 Td
(is)Tj
0.8674 0 Td
(feasible)Tj
3.2428 0 Td
(for)Tj
1.4117 0 Td
(use)Tj
1.559 0 Td
(in)Tj
1.0545 0 Td
(primary)Tj
3.5206 0 Td
(care)Tj
1.9049 0 Td
(consultations)Tj
5.6692 0 Td
(that)Tj
-34.4293 -1.2982 Td
(helps)Tj
2.3414 0 Td
(clinicians)Tj
4.0932 0 Td
(decide)Tj
2.8686 0 Td
(when)Tj
2.4378 0 Td
(antibiotics)Tj
4.5014 0 Td
(can)Tj
1.6497 0 Td
(safely)Tj
2.4832 0 Td
(be)Tj
1.1678 0 Td
(withheld,)Tj
4.0309 0 Td
(or)Tj
1.1111 0 Td
(when)Tj
2.4435 0 Td
(antibiotic)Tj
4.1272 0 Td
(treatment)Tj
-33.2558 -1.304 Td
(is)Tj
0.8673 0 Td
(likely)Tj
2.4038 0 Td
(to)Tj
1.0432 0 Td
(benefit)Tj
3.0387 0 Td
(patients,)Tj
3.6737 0 Td
(could)Tj
2.5001 0 Td
(improve)Tj
3.6453 0 Td
(care)Tj
1.9049 0 Td
(of)Tj
1.0318 0 Td
(this)Tj
1.7121 0 Td
(common)Tj
3.9005 0 Td
(and)Tj
1.7574 0 Td
(important)Tj
4.3597 0 Td
(condition)Tj
4.1952 0 Td
(and)Tj
-36.0337 -1.2982 Td
(help)Tj
1.9672 0 Td
(combat)Tj
3.2655 0 Td
(antibiotic)Tj
4.1272 0 Td
(resistance.)Tj
-8.1637 -1.2983 Td
(A)Tj
0.9184 0 Td
(critical)Tj
3.0217 0 Td
(factor)Tj
2.5965 0 Td
(in)Tj
1.0488 0 Td
(successful)Tj
4.2576 0 Td
(POCT)Tj
2.8347 0 Td
(development)Tj
5.5105 0 Td
(is)Tj
0.8617 0 Td
(gaining)Tj
3.2825 0 Td
(an)Tj
1.2189 0 Td
(in-depth)Tj
3.753 0 Td
(understanding)Tj
6.1852 0 Td
(of)Tj
-36.6857 -1.3039 Td
(the)Tj
1.4966 0 Td
(end)Tj
1.7462 0 Td
(users')Tj
2.5341 0 Td
(\(e.g.)Tj
1.9446 0 Td
(clinicians\))Tj
4.4447 0 Td
(priorities,)Tj
4.1952 0 Td
(needs)Tj
2.5455 0 Td
(and)Tj
1.7575 0 Td
(operational)Tj
4.8755 0 Td
(requirements)Tj
5.6693 0 Td
(for)Tj
1.4116 0 Td
(any)Tj
1.6895 0 Td
(new)Tj
-34.3103 -1.2983 Td
(POCT)Tj
2.8346 0 Td
(at)Tj
0.9694 0 Td
(the)Tj
1.4967 0 Td
(outset)Tj
2.6929 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(],)Tj
2.1203 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
2.1203 0 Td
(This)Tj
2.0239 0 Td
(information,)Tj
5.4085 0 Td
(summarised)Tj
5.2214 0 Td
(in)Tj
1.0545 0 Td
(a)Tj
0.6633 0 Td
(target)Tj
2.5625 0 Td
(product)Tj
3.4582 0 Td
(profile)Tj
-32.6265 -1.2982 Td
(\(TPP\),)Tj
2.9083 0 Td
(should)Tj
2.9707 0 Td
(guide)Tj
2.4774 0 Td
(test)Tj
1.6328 0 Td
(development)Tj
5.5105 0 Td
(so)Tj
1.1055 0 Td
(that)Tj
1.8142 0 Td
(it)Tj
0.805 0 Td
(matches)Tj
3.5716 0 Td
(clinical)Tj
3.1465 0 Td
(need)Tj
2.177 0 Td
(and)Tj
1.7574 0 Td
(safely)Tj
2.4832 0 Td
(improves)Tj
-32.3601 -1.304 Td
(outcomes)Tj
4.1555 0 Td
(in)Tj
1.0545 0 Td
(priority)Tj
3.3505 0 Td
(conditions.)Tj
4.7962 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
2.1203 0 Td
(TPPs)Tj
2.3471 0 Td
(for)Tj
1.4173 0 Td
(diagnosing)Tj
4.6998 0 Td
(infections)Tj
4.2406 0 Td
(disease)Tj
3.0784 0 Td
(have)Tj
2.0977 0 Td
(been)Tj
-33.3579 -1.2982 Td
(developed)Tj
4.3483 0 Td
(by)Tj
1.2019 0 Td
(the)Tj
1.4966 0 Td
(World)Tj
2.8857 0 Td
(Health)Tj
2.9707 0 Td
(Organisation)Tj
5.5729 0 Td
(\(WHO\),)Tj
3.6623 0 Td
(Foundation)Tj
5.0003 0 Td
(for)Tj
1.4173 0 Td
(Innovative)Tj
4.5864 0 Td
(New)Tj
2.0863 0 Td
(Diag-)Tj
-35.2287 -1.2983 Td
(nostics)Tj
3.05 0 Td
(\(FIND\))Tj
3.2938 0 Td
(and)Tj
1.7575 0 Td
(Me)Tj
0 Tc
0.9241 0.051 Td
()Tj
0.005 Tc
0.4082 -0.051 Td
(decines)Tj
3.2598 0 Td
(sans)Tj
1.9559 0 Td
(Frontie)Tj
0 Tc
2.5965 0.051 Td
()Tj
0.005 Tc
0.4139 -0.051 Td
(res)Tj
1.4003 0 Td
(\(MSF\))Tj
2.8403 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(])Tj
1.8878 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(])Tj
1.8879 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(])Tj
1.8879 0 Td
(and)Tj
1.7574 0 Td
(others)Tj
2.761 0 Td
(through)Tj
3.5092 0 Td
(the)Tj
-35.5915 -1.3039 Td
(identification)Tj
5.7089 0 Td
(of)Tj
1.0318 0 Td
(stakeholders)Tj
5.3064 0 Td
(for)Tj
1.4173 0 Td
(consultation,)Tj
5.5276 0 Td
(priority)Tj
3.3448 0 Td
(setting)Tj
2.948 0 Td
(to)Tj
1.0432 0 Td
(identify)Tj
3.3618 0 Td
(the)Tj
1.4967 0 Td
(highest)Tj
3.1578 0 Td
(priority)Tj
-34.3443 -1.2983 Td
(for)Tj
1.4116 0 Td
(test)Tj
1.6384 0 Td
(development,)Tj
5.743 0 Td
(defining)Tj
3.6283 0 Td
(operational)Tj
4.8699 0 Td
(and)Tj
1.7574 0 Td
(technical)Tj
3.8948 0 Td
(test)Tj
1.6384 0 Td
(characteristics,)Tj
6.2702 0 Td
(discussing)Tj
4.4221 0 Td
(dis-)Tj
-35.2741 -1.2982 Td
(puted)Tj
2.5568 0 Td
(criteria,)Tj
3.3845 0 Td
(and)Tj
1.7575 0 Td
(obtaining)Tj
4.1442 0 Td
(final)Tj
2.0466 0 Td
(consensus)Tj
4.3654 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(17)Tj
0 g
(].)Tj
1.7744 0 Td
(To)Tj
1.355 0 Td
(formalise)Tj
4.0195 0 Td
(TTP's)Tj
2.6192 0 Td
(and)Tj
1.7575 0 Td
(ensure)Tj
2.931 0 Td
(their)Tj
-34.4804 -1.2983 Td
(verification)Tj
4.8755 0 Td
(\(consistency)Tj
5.2838 0 Td
(and)Tj
1.7574 0 Td
(completeness\))Tj
6.0321 0 Td
(formal)Tj
2.9367 0 Td
(modelling)Tj
4.354 0 Td
(approaches)Tj
4.8245 0 Td
(have)Tj
2.0976 0 Td
(also)Tj
1.8029 0 Td
(been)Tj
-33.9645 -1.3039 Td
(helpful)Tj
3.0557 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(])Tj
1.8878 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
2.126 0 Td
(However,)Tj
4.1442 0 Td
(as)Tj
1.0375 0 Td
(yet,)Tj
1.6554 0 Td
(there)Tj
2.3074 0 Td
(is)Tj
0.8674 0 Td
(no)Tj
1.2926 0 Td
(consensus)Tj
4.3653 0 Td
(on)Tj
1.2926 0 Td
(the)Tj
1.4967 0 Td
(priority)Tj
3.3449 0 Td
(CA-LRTI)Tj
4.0932 0 Td
(where)Tj
2.6929 0 Td
(a)Tj
-35.6596 -1.2983 Td
(POCT)Tj
2.8346 0 Td
(is)Tj
0.8674 0 Td
(most)Tj
2.2393 0 Td
(urgently)Tj
3.6284 0 Td
(needed,)Tj
3.3845 0 Td
(the)Tj
1.4967 0 Td
(ideal)Tj
2.16 0 Td
(process)Tj
3.2485 0 Td
(for)Tj
1.4116 0 Td
(developing)Tj
4.6941 0 Td
(a)Tj
0.6633 0 Td
(POCT)Tj
2.8347 0 Td
(TPP,)Tj
2.211 0 Td
(and)Tj
1.7575 0 Td
(there)Tj
2.3073 0 Td
(is)Tj
-35.7389 -1.2982 Td
(no)Tj
1.2925 0 Td
(published)Tj
4.2066 0 Td
(TPP)Tj
1.9729 0 Td
(for)Tj
1.4173 0 Td
(a)Tj
0.6633 0 Td
(CA-LRTI)Tj
4.0876 0 Td
(for)Tj
1.4173 0 Td
(use)Tj
1.559 0 Td
(in)Tj
1.0545 0 Td
(developed)Tj
4.3483 0 Td
(countries.)Tj
4.2633 0 Td
(Our)Tj
1.8936 0 Td
(experience)Tj
4.5977 0 Td
(of)Tj
1.0318 0 Td
(develop-)Tj
-33.8057 -1.304 Td
(ing)Tj
1.525 0 Td
(a)Tj
0.6633 0 Td
(TPP)Tj
1.9786 0 Td
(for)Tj
1.4116 0 Td
(the)Tj
1.4967 0 Td
(exemplar)Tj
3.9911 0 Td
(condition)Tj
4.1953 0 Td
(of)Tj
1.0375 0 Td
(CA-LRTI)Tj
4.0875 0 Td
(illustrates)Tj
4.1556 0 Td
(how)Tj
1.9672 0 Td
(a)Tj
0.6633 0 Td
(TPP)Tj
1.9729 0 Td
(can)Tj
1.6554 0 Td
(be)Tj
1.1679 0 Td
(generated)Tj
4.2179 0 Td
(to)Tj
-36.1868 -1.2982 Td
(inform)Tj
3.0727 0 Td
(the)Tj
1.4967 0 Td
(development)Tj
5.5105 0 Td
(of)Tj
1.0318 0 Td
(a)Tj
0.6633 0 Td
(new)Tj
1.9049 0 Td
(POCT.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 201.9968 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Developing)Tj
5.1236 0 Td
(a)Tj
0.7654 0 Td
(target)Tj
2.7354 0 Td
(product)Tj
3.4938 0 Td
(profile)Tj
2.8913 0 Td
(for)Tj
1.3677 0 Td
(a)Tj
0.7654 0 Td
(commu)Tj
3.2315 0 Td
(nity-acqui)Tj
4.1953 0 Td
(red)Tj
1.6441 0 Td
(lower)Tj
2.5583 0 Td
(respiratory)Tj
4.8615 0 Td
(tract)Tj
2.1331 0 Td
(infection)Tj
3.8764 0 Td
(point)Tj
2.3386 0 Td
(of)Tj
1.0417 0 Td
(care)Tj
2.1331 0 Td
(test)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02005)Tj
4.089 0 Td
(31)Tj
0 g
2.0906 0 Td
(August)Tj
3.2882 0 Td
(1,)Tj
1.0418 0 Td
(2018)Tj
34.5758 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(13)Tj
/F9 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(Professor)Tj
3.8268 0 Td
(Herman)Tj
3.1819 0 Td
(Goossens\),)Tj
4.4504 0 Td
(a)Tj
0.6378 0 Td
(public-priva)Tj
4.3512 0 Td
(te)Tj
-16.4481 -1.3748 Td
(partnership)Tj
4.4433 0 Td
(between)Tj
3.3236 0 Td
(the)Tj
1.3678 0 Td
(European)Tj
3.7417 0 Td
(Union)Tj
2.4166 0 Td
(and)Tj
1.5874 0 Td
(the)Tj
-16.8804 -1.3749 Td
(European)Tj
3.7346 0 Td
(Federation)Tj
4.0819 0 Td
(of)Tj
0.9497 0 Td
(Pharmaceutic)Tj
5.0882 0 Td
(al)Tj
0.8362 0 Td
(Industries)Tj
-14.6906 -1.3748 Td
(and)Tj
1.5874 0 Td
(Associations)Tj
4.9181 0 Td
(\(EFPIA\).)Tj
3.2599 0 Td
(EFPIA)Tj
2.4165 0 Td
(companies)Tj
4.2733 0 Td
(and)Tj
-16.4552 -1.3748 Td
(IMI)Tj
1.4811 0 Td
(Associated)Tj
4.252 0 Td
(Partners)Tj
3.352 0 Td
(do)Tj
1.1693 0 Td
(not)Tj
1.4173 0 Td
(receive)Tj
2.8276 0 Td
(any)Tj
1.5378 0 Td
(EU)Tj
-16.0371 -1.3748 Td
(funding)Tj
3.033 0 Td
(through)Tj
3.1536 0 Td
(IMI,)Tj
1.7079 0 Td
(but)Tj
1.4244 0 Td
(contribute)Tj
3.9615 0 Td
(to)Tj
0.9496 0 Td
(IMI)Tj
1.4882 0 Td
(through)Tj
-15.7182 -1.3748 Td
('in)Tj
1.0771 0 Td
(kind')Tj
1.9772 0 Td
(contributio)Tj
3.9898 0 Td
(ns)Tj
1.1197 0 Td
(including)Tj
3.5858 0 Td
(the)Tj
1.3678 0 Td
(time)Tj
1.8425 0 Td
(of)Tj
0.9496 0 Td
(staff)Tj
-15.9095 -1.3748 Td
(employed)Tj
3.848 0 Td
(by)Tj
1.1197 0 Td
(EFPIA)Tj
2.4166 0 Td
(companies)Tj
4.2732 0 Td
(directly)Tj
2.9126 0 Td
(workin)Tj
2.5016 0 Td
(g)Tj
0.6945 0 Td
(on)Tj
-17.7662 -1.3748 Td
(IMI)Tj
1.4811 0 Td
(projects.)Tj
3.4157 0 Td
(The)Tj
1.5875 0 Td
(funder)Tj
2.622 0 Td
(provided)Tj
3.4583 0 Td
(support)Tj
3.0969 0 Td
(in)Tj
0.8858 0 Td
(the)Tj
-16.5473 -1.3748 Td
(form)Tj
2.0126 0 Td
(of)Tj
0.9425 0 Td
(salaries)Tj
3.026 0 Td
(for)Tj
1.2543 0 Td
(authors)Tj
3.0473 0 Td
(\(MG,)Tj
2.0906 0 Td
(NAF,)Tj
1.9772 0 Td
(KH,)Tj
1.559 0 Td
(JV,)Tj
1.389 0 Td
(HG,)Tj
-17.2985 -1.3749 Td
(AW,)Tj
1.7716 0 Td
(CCB\),)Tj
2.3315 0 Td
(but)Tj
1.4245 0 Td
(did)Tj
1.3535 0 Td
(not)Tj
1.4244 0 Td
(have)Tj
1.9559 0 Td
(any)Tj
1.5379 0 Td
(additional)Tj
3.7913 0 Td
(role)Tj
1.6158 0 Td
(in)Tj
-17.2064 -1.3748 Td
(the)Tj
1.3677 0 Td
(study)Tj
2.2677 0 Td
(design,)Tj
2.8985 0 Td
(data)Tj
1.7929 0 Td
(collection)Tj
3.7417 0 Td
(and)Tj
1.5875 0 Td
(analysis,)Tj
-13.656 -1.3748 Td
(decision)Tj
3.2882 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1465 0 Td
(or)Tj
0.9992 0 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-13.7764 -1.3748 Td
(manuscript)Tj
4.4149 0 Td
(.JV)Tj
1.389 0 Td
(was)Tj
1.7008 0 Td
(employed)Tj
3.8552 0 Td
(by)Tj
1.1126 0 Td
(the)Tj
1.3748 0 Td
(commer)Tj
3.1252 0 Td
(cial)Tj
-16.9725 -1.3748 Td
(company,)Tj
3.8834 0 Td
("Janssen)Tj
3.5009 0 Td
(Diagnost)Tj
3.2953 0 Td
(ics)Tj
1.2543 0 Td
(BVBA")Tj
2.5512 0 Td
(\(one)Tj
1.8921 0 Td
(of)Tj
0.9497 0 Td
(the)Tj
-17.3269 -1.3748 Td
(5)Tj
0.6944 0 Td
(EFPIA)Tj
2.4166 0 Td
(member)Tj
3.352 0 Td
(companies)Tj
4.2733 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3748 0 Td
(RAPP-JD)Tj
-13.0607 -1.3748 Td
(consortium)Tj
4.2449 0 Td
(.)Tj
0.4464 0 Td
(Janssen)Tj
3.2741 0 Td
(Diagnost)Tj
3.2953 0 Td
(ics)Tj
1.2614 0 Td
(BVBA)Tj
2.3173 0 Td
(provided)Tj
-14.8394 -1.3749 Td
(support)Tj
3.0968 0 Td
(in)Tj
0.8859 0 Td
(the)Tj
1.3748 0 Td
(form)Tj
2.0055 0 Td
(of)Tj
0.9496 0 Td
(salary)Tj
2.4095 0 Td
(for)Tj
1.2543 0 Td
(author)Tj
2.6221 0 Td
(JV,)Tj
1.389 0 Td
(but)Tj
1.4244 0 Td
(did)Tj
-17.4119 -1.3819 Td
(not)Tj
1.4244 0 Td
(have)Tj
1.9559 0 Td
(any)Tj
1.5378 0 Td
(additiona)Tj
3.3733 0 Td
(l)Tj
0.4181 0 Td
(role)Tj
1.6157 0 Td
(in)Tj
0.8859 0 Td
(the)Tj
1.3677 0 Td
(study)Tj
2.2677 0 Td
(design,)Tj
-14.8465 -1.3748 Td
(data)Tj
1.7929 0 Td
(collection)Tj
3.7347 0 Td
(and)Tj
1.5945 0 Td
(analysis)Tj
2.9622 0 Td
(,)Tj
0.4464 0 Td
(decision)Tj
3.2883 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1465 0 Td
(or)Tj
-17.9151 -1.3748 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
4.6347 0 Td
(The)Tj
1.5945 0 Td
(specific)Tj
3.0189 0 Td
(roles)Tj
2.0339 0 Td
(of)Tj
-18.0426 -1.3748 Td
(the)Tj
1.3677 0 Td
(authors)Tj
3.0472 0 Td
(are)Tj
1.3678 0 Td
(articulated)Tj
4.0606 0 Td
(in)Tj
0.8859 0 Td
(the)Tj
1.3677 0 Td
(author)Tj
-12.0969 -1.3748 Td
(contributio)Tj
3.9897 0 Td
(ns)Tj
1.1197 0 Td
(section.)Tj
/F8 1 Tf
-5.1094 -2.1189 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(Author)Tj
2.7213 0 Td
(JV)Tj
1.1693 0 Td
(was)Tj
1.7008 0 Td
(employed)Tj
3.8552 0 Td
(by)Tj
-17.6387 -1.3819 Td
(the)Tj
1.3677 0 Td
(commercial)Tj
4.5851 0 Td
(compan)Tj
3.0118 0 Td
(y,)Tj
0.8716 0 Td
("Jansse)Tj
2.7993 0 Td
(n)Tj
0.6945 0 Td
(Diagnostic)Tj
3.9118 0 Td
(s)Tj
-17.2418 -1.3748 Td
(BVBA",)Tj
2.7708 0 Td
(which)Tj
2.4166 0 Td
(is)Tj
0.8362 0 Td
(one)Tj
1.5874 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3749 0 Td
(European)Tj
3.7346 0 Td
(Federation)Tj
4.082 0 Td
(of)Tj
-17.7521 -1.3749 Td
(Pharamaceu)Tj
4.6417 0 Td
(tical)Tj
1.7008 0 Td
(Industries)Tj
3.9189 0 Td
(and)Tj
1.5875 0 Td
(Associations)Tj
-11.8489 -1.3748 Td
(\(EFPIA\))Tj
3.033 0 Td
(member)Tj
3.352 0 Td
(companies)Tj
4.2733 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(IMI)Tj
1.4882 0 Td
(RAPP-ID)Tj
-14.4638 -1.3748 Td
(Consortiu)Tj
3.5929 0 Td
(m.)Tj
1.1976 0 Td
(This)Tj
1.7859 0 Td
(does)Tj
2.0055 0 Td
(not)Tj
1.4244 0 Td
(alter)Tj
1.8213 0 Td
(our)Tj
1.474 0 Td
(adherenc)Tj
3.4087 0 Td
(e)Tj
0.6449 0 Td
(to)Tj
-17.3552 -1.3748 Td
(PLOS)Tj
2.3315 0 Td
(ONE)Tj
1.8708 0 Td
(policies)Tj
3.0119 0 Td
(on)Tj
1.1622 0 Td
(sharing)Tj
2.9835 0 Td
(data)Tj
1.7929 0 Td
(and)Tj
ET
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
BT
14.7402 43.4625 Td
(materials.)Tj
ET
Q
endstream
endobj
56 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 59 0 R/Contents 60 0 R/TrimBox[0 0 612 792]>>
endobj
59 0 obj
[61 0 R 62 0 R 63 0 R 64 0 R 65 0 R]
endobj
61 0 obj
<>/Border[0 0 0]/A 66 0 R>>
endobj
66 0 obj
<>
endobj
62 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.t001)>>
endobj
63 0 obj
<>/Border[0 0 0]/Dest(Lpone.0200531.t001)>>
endobj
64 0 obj
<>/Border[0 0 0]/A 67 0 R>>
endobj
67 0 obj
<>
endobj
65 0 obj
<>/Border[0 0 0]/A 68 0 R>>
endobj
68 0 obj
<>
endobj
60 0 obj
[69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R]
endobj
69 0 obj
<>stream
q
0.83 0.64 0.02 0 k
203.4142 570.7276 m
377.348 570.7276 l
h
f*
521.2346 484.4409 m
550.4882 484.4409 l
h
f*
0 g
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 706.0535 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F11 1 Tf
-6.4961 -1.4976 Td
(Ethics)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 671.074 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(This)Tj
1.9842 0 Td
(study)Tj
2.3924 0 Td
(was)Tj
1.6951 0 Td
(reviewed)Tj
3.7984 0 Td
(and)Tj
1.7291 0 Td
(approved)Tj
3.9742 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.474 0 Td
(Cardiff)Tj
3.0557 0 Td
(University)Tj
4.405 0 Td
(School)Tj
2.9084 0 Td
(of)Tj
1.0148 0 Td
(Medicine)Tj
3.9911 0 Td
(Ethics)Tj
-33.6016 -1.2982 Td
(Committee)Tj
4.7394 0 Td
(\(SMREC)Tj
3.7814 0 Td
(Reference)Tj
4.1669 0 Td
(Number)Tj
3.6057 0 Td
(11/32\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 627.8173 cm
BT
/F11 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Study)Tj
2.6173 0 Td
(design)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 610.8094 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(development)Tj
5.4085 0 Td
(of)Tj
1.0148 0 Td
(our)Tj
1.627 0 Td
(CA-LRTI)Tj
4.0309 0 Td
(TPP)Tj
1.9502 0 Td
(was)Tj
1.6951 0 Td
(an)Tj
1.2076 0 Td
(iterative)Tj
3.4582 0 Td
(process)Tj
3.1805 0 Td
(that)Tj
1.7801 0 Td
(included)Tj
3.7134 0 Td
(meetings)Tj
3.8267 0 Td
(with)Tj
-34.6731 -1.3039 Td
(expert)Tj
2.7155 0 Td
(stakeholders)Tj
5.1987 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.474 0 Td
(EU)Tj
1.525 0 Td
(Innovative)Tj
4.4957 0 Td
(Medicines)Tj
4.354 0 Td
(Initiative)Tj
3.8211 0 Td
(\(IMI\))Tj
2.4718 0 Td
(supported)Tj
4.2689 0 Td
(project,)Tj
-32.5301 -1.2982 Td
(`)Tj
/F12 1 Tf
[()-16()14()19()]TJ
/F6 1 Tf
(:)Tj
/F12 1 Tf
4.3653 0 Td
[()2()12()11( )4(\n)]TJ
2.5341 0 Td
[()23()11( )12()22(\r)11()-2()16()20()]TJ
5.5786 0 Td
[()97()8()9(\r)]TJ
1.8312 0 Td
[()9()11()]TJ
1.3152 0 Td
[()39()11()9()7()-4(\r)7( )4()11()-4()]TJ
3.9912 0 Td
[()-4( )-4()-3()7()-3()8()]TJ
/F6 1 Tf
(')Tj
3.6566 0 Td
(\(IMI)Tj
2.1374 0 Td
(RAPP-ID\))Tj
4.4106 0 Td
(project)Tj
3.0161 0 Td
(consortium)Tj
-32.8363 -1.2983 Td
(\()Tj
0.83 0.64 0.02 0 k
(https://www.imi.europa.eu/)Tj
11.3725 0 Td
(content/rapp-id)Tj
0 g
(\))Tj
6.9221 0 Td
(and)Tj
1.7292 0 Td
(a)Tj
0.6519 0 Td
(web-based)Tj
4.4391 0 Td
(survey)Tj
2.8119 0 Td
(targeted)Tj
3.4639 0 Td
(at)Tj
0.9525 0 Td
(practicing)Tj
-32.3431 -1.2983 Td
(primary)Tj
3.4525 0 Td
(care)Tj
1.8766 0 Td
(clinicians)Tj
4.0024 0 Td
(with)Tj
2.0013 0 Td
(an)Tj
1.2019 0 Td
(interest)Tj
3.2088 0 Td
(in)Tj
1.0374 0 Td
(CA-LRTI.)Tj
4.252 0 Td
(Both)Tj
2.1373 0 Td
(qualitative)Tj
4.3767 0 Td
(and)Tj
1.7291 0 Td
(quantitative)Tj
4.9776 0 Td
(data)Tj
-34.2536 -1.3039 Td
(informed)Tj
3.9741 0 Td
(the)Tj
1.4683 0 Td
(TPP.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 515.5086 cm
BT
/F11 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(RAPP-ID)Tj
4.2425 0 Td
(consortium)Tj
5.0363 0 Td
(expert)Tj
2.8583 0 Td
(meetings)Tj
3.9779 0 Td
(and)Tj
1.7953 0 Td
(workshops)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 498.5007 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Four)Tj
2.1543 0 Td
(23)Tj
1.6894 0 Td
(day)Tj
1.6328 0 Td
(RAPP-ID)Tj
4.0705 0 Td
(stakeholder)Tj
4.8359 0 Td
(meetings,)Tj
4.0535 0 Td
(including)Tj
4.0421 0 Td
(breakout)Tj
3.7871 0 Td
(workshops)Tj
4.5524 0 Td
(targeted)Tj
3.4583 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
-35.3024 -1.2982 Td
(specific)Tj
3.1917 0 Td
(disease)Tj
3.0161 0 Td
(areas,)Tj
2.4661 0 Td
(were)Tj
2.126 0 Td
(conducted)Tj
4.4277 0 Td
(between)Tj
3.5262 0 Td
(April)Tj
2.3074 0 Td
(2011)Tj
2.1203 0 Td
(and)Tj
1.7348 0 Td
(January)Tj
3.3165 0 Td
(2012)Tj
2.126 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7632 0 Td
(Table)Tj
2.4434 0 Td
(1)Tj
0 g
0.6973 0 Td
(for)Tj
-35.2627 -1.2983 Td
(meeting)Tj
3.4639 0 Td
(objectives\).)Tj
4.7054 0 Td
(Stakeholders)Tj
5.3178 0 Td
(included)Tj
3.7077 0 Td
(expert)Tj
2.7212 0 Td
(and)Tj
1.7292 0 Td
(practicing)Tj
4.2349 0 Td
(clinicians,)Tj
4.2349 0 Td
(microbiologists,)Tj
-30.115 -1.3039 Td
(scientists)Tj
3.8267 0 Td
(\(molecular)Tj
4.5581 0 Td
(microbiology,)Tj
5.7883 0 Td
(chemistry)Tj
4.1669 0 Td
(and)Tj
1.7348 0 Td
(physics\),)Tj
3.6963 0 Td
(diagnostic)Tj
4.32 0 Td
(market)Tj
3.0614 0 Td
(experts)Tj
3.0784 0 Td
(and)Tj
1.7348 0 Td
(test)Tj
-35.9657 -1.2983 Td
(developers)Tj
4.473 0 Td
(from)Tj
2.2053 0 Td
(academia)Tj
3.9855 0 Td
(and)Tj
1.7291 0 Td
(industry)Tj
3.5773 0 Td
(\(European)Tj
4.4617 0 Td
(Federation)Tj
4.5468 0 Td
(of)Tj
1.0148 0 Td
(Pharmaceutical)Tj
6.4062 0 Td
(Industries)Tj
-32.3997 -1.2982 Td
(and)Tj
1.7291 0 Td
(Associations)Tj
5.2384 0 Td
(\(EFPIA\)\))Tj
3.9231 0 Td
(in)Tj
1.0318 0 Td
(Europe.)Tj
3.3619 0 Td
(Learning)Tj
3.821 0 Td
(points)Tj
2.7156 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(TRANS-Atlantic)Tj
6.8995 0 Td
(Task)Tj
2.1259 0 Td
(Force)Tj
-34.52 -1.3039 Td
(on)Tj
1.2755 0 Td
(Antimicrobial)Tj
5.862 0 Td
(Resistance)Tj
4.3767 0 Td
(\(TATFAR\))Tj
4.6431 0 Td
(meeting)Tj
3.4639 0 Td
(on)Tj
/F12 1 Tf
1.2756 0 Td
[()30()1()6()11()4()4()2()13()2()8()]TJ
4.5694 0 Td
[()16()6(\n)]TJ
1.7292 0 Td
[()-3()10()12()14(\r)7( )4()11()]TJ
3.668 0 Td
[( )12()]TJ
1.0148 0 Td
[(\r)10()6()]TJ
1.4173 0 Td
[(\n)4()-5()3()15()4()11()]TJ
-33.2955 -1.2983 Td
[()6()2()22(\r)]TJ
2.2166 0 Td
[()11()]TJ
0.9525 0 Td
[()6()-5()]TJ
1.8028 0 Td
[(\n)12( )4()15()-8()6()7()9(\r)7( )4()]TJ
4.1385 0 Td
[(\r)11()8()9(\r)]TJ
1.8709 0 Td
[(\r)11()]TJ
0.9808 0 Td
[()7()11()17()4()22(\r)]TJ
3.0954 0 Td
[()16()22(\r)7( )12()18( )4()1()20()13()11( )4()11()]TJ
5.5105 0 Td
[()20()8()10( )-4()9(\r)11()16()6()7()57()]TJ
/F6 1 Tf
4.1783 0 Td
(informed)Tj
3.9741 0 Td
(stakeholder)Tj
-28.7204 -1.2983 Td
(discussions.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 364.2519 cm
BT
/F11 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(User)Tj
2.1637 0 Td
(survey)Tj
2.915 0 Td
(for)Tj
1.4693 0 Td
(CA-LRTI)Tj
4.1528 0 Td
(POCT)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 347.244 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(An)Tj
1.4513 0 Td
(on-line)Tj
3.1124 0 Td
(survey,)Tj
3.0387 0 Td
(informed)Tj
3.9742 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(stakeholder)Tj
4.8359 0 Td
(meeting)Tj
3.4696 0 Td
(outputs,)Tj
3.4809 0 Td
(was)Tj
1.7008 0 Td
(developed)Tj
4.2689 0 Td
(in)Tj
1.0375 0 Td
(collabora-)Tj
-33.0177 -1.3039 Td
(tion)Tj
1.8425 0 Td
(with)Tj
1.9955 0 Td
(RAPP-ID)Tj
4.0706 0 Td
(consortium)Tj
4.8528 0 Td
(members)Tj
3.9402 0 Td
(to)Tj
1.0261 0 Td
(ensure)Tj
2.88 0 Td
(questions)Tj
4.0195 0 Td
(covered)Tj
3.3505 0 Td
(information)Tj
5.074 0 Td
(required)Tj
-33.0517 -1.2982 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(test)Tj
1.6044 0 Td
(developers.)Tj
4.6998 0 Td
(The)Tj
1.7802 0 Td
(survey)Tj
2.8176 0 Td
(was)Tj
1.6951 0 Td
(piloted)Tj
3.0104 0 Td
(prior)Tj
2.2506 0 Td
(to)Tj
1.0262 0 Td
(distribution.)Tj
5.193 0 Td
(Data)Tj
2.126 0 Td
(collection)Tj
4.1102 0 Td
(was)Tj
1.6951 0 Td
(from)Tj
-34.6561 -1.2983 Td
(12th)Tj
1.9955 0 Td
(September)Tj
4.4787 0 Td
(to)Tj
1.0262 0 Td
(12)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 284.5417 312.6614 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(th)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 292.9322 308.2393 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(December)Tj
4.3483 0 Td
(2011.)Tj
2.347 0 Td
(The)Tj
1.7802 0 Td
(survey)Tj
2.8119 0 Td
(was)Tj
1.7008 0 Td
(aimed)Tj
2.6929 0 Td
(at)Tj
0.9524 0 Td
(practicing)Tj
4.235 0 Td
(primary)Tj
3.4582 0 Td
(care)Tj
1.8709 0 Td
(clini-)Tj
-35.4895 -1.3039 Td
(cians)Tj
2.2507 0 Td
(with)Tj
2.0013 0 Td
(an)Tj
1.2019 0 Td
(interest)Tj
3.2088 0 Td
(in)Tj
1.0373 0 Td
(respiratory)Tj
4.5978 0 Td
(tract)Tj
2.0466 0 Td
(infections)Tj
4.1499 0 Td
(and)Tj
1.7291 0 Td
(was)Tj
1.7008 0 Td
(disseminated)Tj
5.4765 0 Td
(through)Tj
3.4469 0 Td
(RAPP-ID)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
200.0001 267.1177 m
576 267.1177 l
576 266.6177 l
200.0001 266.6177 l
f*
213.552 266.6177 m
213.552 254.1178 l
213.052 254.1178 l
213.052 266.6177 l
f*
213.052 254.1178 m
200.0001 254.1178 l
200.0001 254.6178 l
213.052 254.6178 l
f*
576 254.1178 m
213.552 254.1178 l
213.552 254.6178 l
576 254.6178 l
f*
213.552 254.1178 m
213.552 241.6178 l
213.052 241.6178 l
213.052 254.1178 l
f*
213.052 241.6178 m
200.0001 241.6178 l
200.0001 242.1179 l
213.052 242.1179 l
f*
576 241.6178 m
213.552 241.6178 l
213.552 242.1179 l
576 242.1179 l
f*
213.552 241.6178 m
213.552 229.1179 l
213.052 229.1179 l
213.052 241.6178 l
f*
213.052 229.1179 m
200.0001 229.1179 l
200.0001 229.6179 l
213.052 229.6179 l
f*
576 229.1179 m
213.552 229.1179 l
213.552 229.6179 l
576 229.6179 l
f*
213.552 229.1179 m
213.552 207.1179 l
213.052 207.1179 l
213.052 229.1179 l
f*
213.052 207.1179 m
200.0001 207.1179 l
200.0001 207.618 l
213.052 207.618 l
f*
576 207.1179 m
213.552 207.1179 l
213.552 207.618 l
576 207.618 l
f*
213.552 207.1179 m
213.552 194.618 l
213.052 194.618 l
213.052 207.1179 l
f*
213.052 194.618 m
200.0001 194.618 l
200.0001 195.118 l
213.052 195.118 l
f*
576 194.618 m
213.552 194.618 l
213.552 195.118 l
576 195.118 l
f*
213.552 194.618 m
213.552 182.118 l
213.052 182.118 l
213.052 194.618 l
f*
213.052 182.118 m
200.0001 182.118 l
200.0001 182.6181 l
213.052 182.6181 l
f*
576 182.118 m
213.552 182.118 l
213.552 182.6181 l
576 182.6181 l
f*
213.552 182.118 m
213.552 160.1181 l
213.052 160.1181 l
213.052 182.118 l
f*
213.052 160.1181 m
200.0001 160.1181 l
200.0001 160.6181 l
213.052 160.6181 l
f*
576 160.1181 m
213.552 160.1181 l
213.552 160.6181 l
576 160.6181 l
f*
213.552 160.1181 m
213.552 147.6181 l
213.052 147.6181 l
213.052 160.1181 l
f*
213.052 147.6181 m
200.0001 147.6181 l
200.0001 148.1182 l
213.052 148.1182 l
f*
576 147.6181 m
213.552 147.6181 l
213.552 148.1182 l
576 148.1182 l
f*
213.552 147.6181 m
213.552 135.1182 l
213.052 135.1182 l
213.052 147.6181 l
f*
213.052 135.1182 m
200.0001 135.1182 l
200.0001 135.6182 l
213.052 135.6182 l
f*
576 135.1182 m
213.552 135.1182 l
213.552 135.6182 l
576 135.6182 l
f*
213.552 135.1182 m
213.552 122.6183 l
213.052 122.6183 l
213.052 135.1182 l
f*
213.052 122.6183 m
200.0001 122.6183 l
200.0001 123.1183 l
213.052 123.1183 l
f*
576 122.6183 m
213.552 122.6183 l
213.552 123.1183 l
576 123.1183 l
f*
213.552 122.6183 m
213.552 100.6183 l
213.052 100.6183 l
213.052 122.6183 l
f*
213.052 100.6183 m
200.0001 100.6183 l
200.0001 101.1183 l
213.052 101.1183 l
f*
576 100.6183 m
213.552 100.6183 l
213.552 101.1183 l
576 101.1183 l
f*
0.83 0.64 0.02 0 k
200.0126 87.5339 m
350.7591 87.5339 l
h
f*
0 g
7.9999 0 0 7.9999 200.0125 271.9559 cm
BT
/F11 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(1.)Tj
1.1763 0 Td
(Objective)Tj
3.9402 0 Td
(s)Tj
0.6024 0 Td
(of)Tj
1.063 0 Td
(the)Tj
1.5307 0 Td
(stakeholder)Tj
5.0457 0 Td
(planning)Tj
3.9402 0 Td
(meetings.)Tj
0 Tc
-19.8497 -1.8567 Td
(No)Tj
1.9417 0 Td
(Objective)Tj
-1.9417 -1.559 Td
(1)Tj
/F6 1 Tf
2.0693 0 Td
(Familiar)Tj
3.3803 0 Td
(ise)Tj
1.2898 0 Td
(all)Tj
1.1693 0 Td
(stakeholde)Tj
4.2661 0 Td
(rs)Tj
0.9638 0 Td
(with)Tj
2.0197 0 Td
(the)Tj
1.4882 0 Td
(expertise)Tj
3.7985 0 Td
(and)Tj
1.7433 0 Td
(technologies)Tj
5.2583 0 Td
(available)Tj
3.6993 0 Td
(within)Tj
2.8346 0 Td
(the)Tj
1.4882 0 Td
(consortium)Tj
/F11 1 Tf
-35.4687 -1.5662 Td
(2)Tj
/F6 1 Tf
2.0693 0 Td
(Discuss)Tj
3.2811 0 Td
(potential)Tj
3.7914 0 Td
(benefits)Tj
3.3661 0 Td
(of)Tj
1.0276 0 Td
(optimised)Tj
4.2378 0 Td
(disease)Tj
3.0473 0 Td
(diagnosis)Tj
/F11 1 Tf
-20.8206 -1.559 Td
(3)Tj
/F6 1 Tf
2.0693 0 Td
(Reach)Tj
2.6716 0 Td
(agreemen)Tj
3.919 0 Td
(t)Tj
0.5315 0 Td
(on)Tj
1.2897 0 Td
(target)Tj
2.5371 0 Td
(condition)Tj
3.9118 0 Td
(s)Tj
0.5953 0 Td
(that)Tj
1.8 0 Td
(would)Tj
2.7284 0 Td
(most)Tj
2.2252 0 Td
(benefit)Tj
3.0047 0 Td
(from)Tj
2.2252 0 Td
(improved)Tj
4.1316 0 Td
(diagnosis)Tj
3.9898 0 Td
(for)Tj
1.4031 0 Td
(adequate)Tj
-36.964 -1.1906 Td
(antimic)Tj
3.0685 0 Td
(robial)Tj
2.5795 0 Td
(treatment)Tj
/F11 1 Tf
-7.7173 -1.5591 Td
(4)Tj
/F6 1 Tf
2.0693 0 Td
(Consider)Tj
3.9118 0 Td
(the)Tj
1.4882 0 Td
(clinical)Tj
3.104 0 Td
(complexity)Tj
4.6772 0 Td
(of)Tj
1.0275 0 Td
(antibiotic)Tj
4.0749 0 Td
(treatment)Tj
4.1669 0 Td
(decisions)Tj
/F11 1 Tf
-24.5198 -1.5661 Td
(5)Tj
/F6 1 Tf
2.0693 0 Td
(Clarify)Tj
2.9693 0 Td
(the)Tj
1.4882 0 Td
(current)Tj
3.2102 0 Td
(state)Tj
2.0552 0 Td
(of)Tj
1.0275 0 Td
(the)Tj
1.4882 0 Td
(art)Tj
1.3394 0 Td
(in)Tj
1.0559 0 Td
(diagnost)Tj
3.4229 0 Td
(ic)Tj
0.9283 0 Td
(tools)Tj
2.1615 0 Td
(for)Tj
1.4031 0 Td
(each)Tj
2.0481 0 Td
(disease)Tj
3.0402 0 Td
(condition)Tj
/F11 1 Tf
-29.7073 -1.5591 Td
(6)Tj
/F6 1 Tf
2.0693 0 Td
(Reach)Tj
2.6716 0 Td
(agreemen)Tj
3.919 0 Td
(t)Tj
0.5315 0 Td
(on)Tj
1.2897 0 Td
(micro-organ)Tj
5.0883 0 Td
(isms,)Tj
2.2748 0 Td
(biomarkers)Tj
4.8118 0 Td
(and)Tj
1.7434 0 Td
(thresholds)Tj
4.4079 0 Td
(\(e.g.)Tj
1.9205 0 Td
(limit)Tj
2.1401 0 Td
(of)Tj
1.0347 0 Td
(detect)Tj
2.4024 0 Td
(ion,)Tj
1.7929 0 Td
(colonisation)Tj
5.1733 0 Td
(vs.)Tj
-41.2019 -1.1906 Td
(infection\))Tj
/F11 1 Tf
-2.0693 -1.559 Td
(7)Tj
/F6 1 Tf
2.0693 0 Td
(Discuss)Tj
3.2811 0 Td
(the)Tj
1.4882 0 Td
(availabili)Tj
3.5788 0 Td
(ty)Tj
0.9921 0 Td
(and)Tj
1.7433 0 Td
(challenge)Tj
3.7559 0 Td
(s)Tj
0.5953 0 Td
(of)Tj
1.0276 0 Td
(clinical)Tj
3.111 0 Td
(sample)Tj
3.0402 0 Td
(availability,)Tj
4.8048 0 Td
(collect)Tj
2.5795 0 Td
(ion)Tj
1.5591 0 Td
(and)Tj
1.7504 0 Td
(processi)Tj
3.2457 0 Td
(ng)Tj
/F11 1 Tf
-38.6223 -1.5662 Td
(8)Tj
/F6 1 Tf
2.0693 0 Td
(Develop)Tj
3.5504 0 Td
(models)Tj
3.1252 0 Td
(of)Tj
1.0347 0 Td
(therap)Tj
2.5795 0 Td
(eutic)Tj
2.1827 0 Td
(algorithms)Tj
4.5496 0 Td
(and)Tj
1.7504 0 Td
(patient)Tj
3.0331 0 Td
(stratification)Tj
5.3292 0 Td
(including)Tj
4.0678 0 Td
(POCT)Tj
2.8205 0 Td
(integration)Tj
/F11 1 Tf
-36.0924 -1.559 Td
(9)Tj
/F6 1 Tf
2.0693 0 Td
(Discuss)Tj
3.2811 0 Td
(potential)Tj
3.7914 0 Td
(scenarios)Tj
3.9472 0 Td
(from)Tj
2.2252 0 Td
(sample)Tj
3.0402 0 Td
(collection)Tj
4.1457 0 Td
(to)Tj
1.0418 0 Td
(read-out)Tj
/F11 1 Tf
-23.5419 -1.5662 Td
(10)Tj
/F6 1 Tf
2.0693 0 Td
(Develop)Tj
3.5504 0 Td
(the)Tj
1.4882 0 Td
(user)Tj
1.9205 0 Td
(survey)Tj
2.8346 0 Td
(and)Tj
1.7504 0 Td
(discussing)Tj
4.3583 0 Td
(the)Tj
1.4882 0 Td
(technical)Tj
3.841 0 Td
(feasibility)Tj
4.0749 0 Td
(of)Tj
1.0275 0 Td
(including)Tj
4.0749 0 Td
(the)Tj
1.4882 0 Td
(identified)Tj
4.089 0 Td
(ideal)Tj
2.1401 0 Td
(user)Tj
-38.1262 -1.1835 Td
(requirement)Tj
5.0031 0 Td
(s)Tj
0.83 0.64 0.02 0 k
/F9 1 Tf
-0.025 Tc
-7.0724 -1.8779 Td
(https://d)Tj
3.0827 0 Td
(oi.org/10.1371/j)Tj
5.9173 0 Td
(ournal.pon)Tj
3.9827 0 Td
(e.0200531.t00)Tj
5.3859 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 201.9968 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Developing)Tj
5.1236 0 Td
(a)Tj
0.7654 0 Td
(target)Tj
2.7354 0 Td
(product)Tj
3.4938 0 Td
(profile)Tj
2.8913 0 Td
(for)Tj
1.3677 0 Td
(a)Tj
0.7654 0 Td
(commu)Tj
3.2315 0 Td
(nity-acqui)Tj
4.1953 0 Td
(red)Tj
1.6441 0 Td
(lower)Tj
2.5583 0 Td
(respiratory)Tj
4.8615 0 Td
(tract)Tj
2.1331 0 Td
(infection)Tj
3.8764 0 Td
(point)Tj
2.3386 0 Td
(of)Tj
1.0417 0 Td
(care)Tj
2.1331 0 Td
(test)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02005)Tj
4.089 0 Td
(31)Tj
0 g
2.0906 0 Td
(August)Tj
3.2882 0 Td
(1,)Tj
1.0418 0 Td
(2018)Tj
34.5758 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
70 0 obj
<>stream
endstream
endobj
71 0 obj
<>stream
endstream
endobj
72 0 obj
<>stream
endstream
endobj
73 0 obj
<>stream
endstream
endobj
74 0 obj
<>stream
endstream
endobj
75 0 obj
<>stream
endstream
endobj
76 0 obj
<>stream
BT
66.402 0 Td
(13)Tj
ET
Q
endstream
endobj
77 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 79 0 R/Contents 80 0 R/TrimBox[0 0 612 792]>>
endobj
79 0 obj
[81 0 R 82 0 R 83 0 R 84 0 R]
endobj
81 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.g001)>>
endobj
82 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.s001)>>
endobj
83 0 obj
<>/Border[0 0 0]/Dest(Rpone.0200531.t002)>>
endobj
84 0 obj
<>/Border[0 0 0]/A 85 0 R>>
endobj
85 0 obj
<>
endobj
80 0 obj
[86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R]
endobj
86 0 obj
<>stream
q
0.83 0.64 0.02 0 k
319.6346 680.315 m
339.137 680.315 l
h
f*
452.8063 654.3496 m
486.7654 654.3496 l
h
f*
267.8173 302.0598 m
296.9575 302.0598 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(partners,)Tj
3.77 0 Td
(the)Tj
1.4683 0 Td
(General)Tj
3.3846 0 Td
(Practice)Tj
3.4185 0 Td
(Respiratory)Tj
4.8473 0 Td
(Infections)Tj
4.2236 0 Td
(Network)Tj
3.7417 0 Td
(\(GRIN\),)Tj
3.5376 0 Td
(and)Tj
1.7291 0 Td
(flyers)Tj
2.3641 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(Euro-)Tj
-34.9056 -1.3039 Td
(pean)Tj
2.1429 0 Td
(Respiratory)Tj
4.8472 0 Td
(Society)Tj
3.0671 0 Td
(Annual)Tj
3.2088 0 Td
(meeting)Tj
3.4696 0 Td
(\(Netherlands,)Tj
5.6806 0 Td
(September)Tj
4.4787 0 Td
(2011\).)Tj
-25.6987 -1.2982 Td
(The)Tj
1.7858 0 Td
(survey)Tj
2.8119 0 Td
(had)Tj
1.7121 0 Td
(four)Tj
1.9106 0 Td
(parts)Tj
2.2053 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8199 0 Td
(1)Tj
0 g
(\).)Tj
1.2585 0 Td
(Part)Tj
1.8822 0 Td
(1)Tj
0.6973 0 Td
(aimed)Tj
2.6929 0 Td
(to)Tj
1.0262 0 Td
(identify)Tj
3.2938 0 Td
(the)Tj
1.4683 0 Td
(priority)Tj
3.2712 0 Td
(clinical)Tj
3.0784 0 Td
(LRTI)Tj
2.3301 0 Td
(sub-)Tj
-34.4407 -1.2983 Td
(conditions)Tj
4.473 0 Td
(that)Tj
1.7801 0 Td
(clinician's)Tj
4.2236 0 Td
(considered)Tj
4.5978 0 Td
(would)Tj
2.7156 0 Td
(most)Tj
2.2053 0 Td
(benefit)Tj
2.9764 0 Td
(from)Tj
2.2053 0 Td
(improved)Tj
4.1046 0 Td
(rapid)Tj
2.3414 0 Td
(diagnostics.)Tj
-31.6231 -1.2983 Td
(Clinical)Tj
3.3165 0 Td
(case)Tj
1.8595 0 Td
(definitions)Tj
4.524 0 Td
(for)Tj
1.389 0 Td
(each)Tj
2.0239 0 Td
(LRTI)Tj
2.3358 0 Td
(sub-type)Tj
3.6566 0 Td
(were)Tj
2.126 0 Td
(included)Tj
3.7077 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1)Tj
1.5137 0 Td
(Table)Tj
0 g
(\).)Tj
3.0047 0 Td
(Part)Tj
1.8822 0 Td
(2)Tj
0.6973 0 Td
(asked)Tj
2.4661 0 Td
(about)Tj
-34.503 -1.3039 Td
(clinician's)Tj
4.2179 0 Td
(ideal)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(minimum)Tj
4.2916 0 Td
(user)Tj
1.9049 0 Td
(specifications)Tj
5.6069 0 Td
(for)Tj
1.3833 0 Td
(a)Tj
0.6576 0 Td
(CA-LRTI)Tj
4.0252 0 Td
(POCT.)Tj
3.0274 0 Td
(Parts)Tj
2.245 0 Td
(3)Tj
0.6917 0 Td
(and)Tj
1.7347 0 Td
(4)Tj
0.6917 0 Td
(asked)Tj
-34.3273 -1.2982 Td
(about)Tj
2.4944 0 Td
(clinician's)Tj
4.2179 0 Td
(current)Tj
3.1862 0 Td
(POCT)Tj
2.8006 0 Td
(use)Tj
1.5307 0 Td
(and)Tj
1.7291 0 Td
(barriers)Tj
3.3279 0 Td
(to)Tj
1.0261 0 Td
(implementing)Tj
5.862 0 Td
(POCT)Tj
2.8006 0 Td
(`s)Tj
0.8107 0 Td
(in)Tj
1.0318 0 Td
(routine)Tj
3.1635 0 Td
(care)Tj
1.8765 0 Td
(and)Tj
-35.858 -1.2983 Td
(microbiologists.)Tj
1.1962 -1.3039 Td
(Questions)Tj
4.2632 0 Td
(to)Tj
1.0262 0 Td
(identify)Tj
3.2938 0 Td
(clinical)Tj
3.0784 0 Td
(priority)Tj
3.2712 0 Td
(or)Tj
1.0998 0 Td
(need)Tj
2.143 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(POCT)Tj
2.8006 0 Td
(asked)Tj
2.4605 0 Td
(respondents)Tj
5.108 0 Td
(to)Tj
1.0261 0 Td
(i\))Tj
0.8277 0 Td
(select)Tj
-34.452 -1.2983 Td
(their)Tj
2.1089 0 Td
(ideal)Tj
2.1146 0 Td
(requirement)Tj
5.2044 0 Td
(and)Tj
1.7291 0 Td
(ii\))Tj
1.0942 0 Td
(and)Tj
1.7291 0 Td
(assign)Tj
2.6589 0 Td
(a)Tj
0.652 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(1)Tj
0.6974 0 Td
(to)Tj
1.0261 0 Td
(5)Tj
0.6916 0 Td
(\(1-highest)Tj
4.2577 0 Td
(priority)Tj
3.2768 0 Td
(to)Tj
1.0261 0 Td
(5-lowest)Tj
-32.7002 -1.2983 Td
(priority\))Tj
3.6113 0 Td
(for)Tj
1.3889 0 Td
(their)Tj
2.109 0 Td
(the)Tj
1.4683 0 Td
(requirement)Tj
5.1987 0 Td
(they)Tj
1.9276 0 Td
(considered)Tj
4.5978 0 Td
(most)Tj
2.2053 0 Td
(essential.)Tj
3.8097 0 Td
(To)Tj
1.338 0 Td
(determine)Tj
4.3256 0 Td
(the)Tj
1.4684 0 Td
(POCT)Tj
-33.4486 -1.3039 Td
(technical)Tj
3.8097 0 Td
(specifications,)Tj
5.8337 0 Td
(respondents)Tj
5.108 0 Td
(were)Tj
2.1203 0 Td
(asked)Tj
2.4661 0 Td
(to)Tj
1.0261 0 Td
(i\))Tj
0.8221 0 Td
(select)Tj
2.3981 0 Td
(their)Tj
2.1089 0 Td
(ideal)Tj
2.1203 0 Td
(requirement)Tj
5.1987 0 Td
(and)Tj
1.7291 0 Td
(mini-)Tj
-34.7411 -1.2982 Td
(mally)Tj
2.4207 0 Td
(acceptable)Tj
4.3483 0 Td
(requirement,)Tj
5.4255 0 Td
(and)Tj
1.7348 0 Td
(ii\))Tj
1.0942 0 Td
(select)Tj
2.3924 0 Td
(yes/no)Tj
2.846 0 Td
(for)Tj
1.3889 0 Td
(questions)Tj
4.0195 0 Td
(asking)Tj
2.7893 0 Td
(if)Tj
0.7767 0 Td
(they)Tj
1.9219 0 Td
(would)Tj
2.7156 0 Td
(consider)Tj
-33.8738 -1.2983 Td
(using)Tj
2.3867 0 Td
(a)Tj
0.6576 0 Td
(test)Tj
1.5988 0 Td
(with)Tj
1.9955 0 Td
(the)Tj
1.4741 0 Td
(listed)Tj
2.3414 0 Td
(characteristics.)Tj
6.1284 0 Td
(For)Tj
1.6271 0 Td
(all)Tj
1.1452 0 Td
(questions)Tj
4.0252 0 Td
(respondents)Tj
5.108 0 Td
(could)Tj
2.4491 0 Td
(select)Tj
2.3981 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
-35.6766 -1.3039 Td
(one)Tj
1.6951 0 Td
(option)Tj
2.8686 0 Td
(and)Tj
1.7291 0 Td
(provide)Tj
3.2882 0 Td
(free)Tj
1.7291 0 Td
(text)Tj
1.7008 0 Td
(comments.)Tj
4.6488 0 Td
(Options)Tj
3.4639 0 Td
(for)Tj
1.389 0 Td
(`unsure')Tj
3.4185 0 Td
(and)Tj
1.7291 0 Td
(`not)Tj
1.8029 0 Td
(relevant)Tj
3.4185 0 Td
(to)Tj
1.0262 0 Td
(my)Tj
1.4967 0 Td
(prac-)Tj
-35.4045 -1.2983 Td
(tice')Tj
1.8481 0 Td
(were)Tj
2.1203 0 Td
(included.)Tj
-2.7722 -1.2982 Td
(The)Tj
1.7858 0 Td
(results)Tj
2.8063 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(user)Tj
1.8992 0 Td
(survey)Tj
2.8176 0 Td
(were)Tj
2.1203 0 Td
(presented)Tj
4.1159 0 Td
(to)Tj
1.0261 0 Td
(all)Tj
1.1452 0 Td
(RAPP-ID)Tj
4.0705 0 Td
(partners)Tj
3.5433 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(technical)Tj
3.8098 0 Td
(fea-)Tj
-36.0281 -1.2983 Td
(sibility)Tj
2.8856 0 Td
(of)Tj
1.0148 0 Td
(including)Tj
4.0422 0 Td
(the)Tj
1.4683 0 Td
(ideal)Tj
2.1203 0 Td
(user)Tj
1.9049 0 Td
(requirements)Tj
5.5615 0 Td
(into)Tj
1.8425 0 Td
(a)Tj
0.652 0 Td
(POCT)Tj
2.8006 0 Td
(discussed)Tj
4.0025 0 Td
(with)Tj
1.9956 0 Td
(guidance)Tj
3.8381 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
-36.3342 -1.3039 Td
(expert)Tj
2.7155 0 Td
(clinicians)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 444.2456 cm
BT
/F11 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Survey)Tj
3.0283 0 Td
(data)Tj
2.041 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 427.2944 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Survey)Tj
2.9253 0 Td
(results)Tj
2.8119 0 Td
(were)Tj
2.1203 0 Td
(combined)Tj
4.2463 0 Td
(for)Tj
1.3833 0 Td
(all)Tj
1.1452 0 Td
(countries)Tj
3.9515 0 Td
(to)Tj
1.0261 0 Td
(inform)Tj
3.0217 0 Td
(the)Tj
1.4684 0 Td
(TPP.)Tj
2.1713 0 Td
(Questions)Tj
4.2633 0 Td
(asking)Tj
2.7892 0 Td
(respon-)Tj
-33.3238 -1.3039 Td
(dents)Tj
2.3754 0 Td
(to)Tj
1.0261 0 Td
(select)Tj
2.3981 0 Td
(their)Tj
2.109 0 Td
(ideal)Tj
2.1146 0 Td
(requirements)Tj
5.5672 0 Td
(and)Tj
1.7291 0 Td
(responses)Tj
4.0932 0 Td
(to)Tj
1.0262 0 Td
(binary)Tj
2.8006 0 Td
(\(yes/no\))Tj
3.5263 0 Td
(questions)Tj
4.0195 0 Td
(were)Tj
2.1203 0 Td
(ana-)Tj
-34.9056 -1.2982 Td
(lysed)Tj
2.2336 0 Td
(as)Tj
1.0148 0 Td
(number)Tj
3.4186 0 Td
(and)Tj
1.7291 0 Td
(proportion)Tj
4.6318 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(average.)Tj
3.4526 0 Td
(For)Tj
1.627 0 Td
(ranking)Tj
3.3506 0 Td
(questions,)Tj
4.2462 0 Td
(the)Tj
1.4684 0 Td
(majority)Tj
3.6283 0 Td
(of)Tj
-33.0177 -1.2983 Td
(respondents)Tj
5.1079 0 Td
(selected)Tj
3.3449 0 Td
(and)Tj
1.7291 0 Td
(scored)Tj
2.8347 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(one)Tj
1.7007 0 Td
(priority)Tj
3.2712 0 Td
(for)Tj
1.389 0 Td
(each)Tj
2.0296 0 Td
(question.)Tj
3.8834 0 Td
(These)Tj
2.5682 0 Td
(results)Tj
2.8062 0 Td
(were)Tj
-35.0359 -1.3039 Td
(therefore)Tj
3.855 0 Td
(also)Tj
1.7632 0 Td
(analysed)Tj
3.651 0 Td
(as)Tj
1.0148 0 Td
(numbers)Tj
3.7814 0 Td
(and)Tj
1.7291 0 Td
(proportions)Tj
4.9946 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(average.)Tj
3.4526 0 Td
(Free)Tj
1.9615 0 Td
(text)Tj
1.7065 0 Td
(comments)Tj
4.422 0 Td
(were)Tj
-34.5484 -1.2983 Td
(included)Tj
3.7133 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(appendix)Tj
3.9231 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(TTP.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 333.1275 cm
BT
/F11 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Target)Tj
2.9858 0 Td
(product)Tj
3.5481 0 Td
(profile)Tj
3.0189 0 Td
(\(TPP\))Tj
2.7638 0 Td
(document)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 316.1196 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Information)Tj
5.1476 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(stakeholder)Tj
4.8416 0 Td
(meetings)Tj
3.8267 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(user)Tj
1.9048 0 Td
(survey)Tj
2.812 0 Td
(were)Tj
2.1203 0 Td
(used)Tj
2.0636 0 Td
(to)Tj
1.0261 0 Td
(design)Tj
2.812 0 Td
(and)Tj
-33.4259 -1.2982 Td
(inform)Tj
3.0217 0 Td
(the)Tj
1.4683 0 Td
(TPP)Tj
1.9502 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.778 0 Td
(2)Tj
0 g
(\).)Tj
1.2642 0 Td
(Stakeholder)Tj
4.9493 0 Td
(discussions)Tj
4.7338 0 Td
(aimed)Tj
2.6929 0 Td
(to)Tj
1.0261 0 Td
(reach)Tj
2.3981 0 Td
(consensus)Tj
4.2803 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.474 0 Td
(final)Tj
2.0012 0 Td
(TPP)Tj
-35.3137 -1.2983 Td
(including)Tj
4.0421 0 Td
(the)Tj
1.4684 0 Td
(specifications)Tj
5.6069 0 Td
(for)Tj
1.3833 0 Td
(a)Tj
0.6576 0 Td
(CA-LRTI)Tj
4.0252 0 Td
(POCT)Tj
2.8006 0 Td
(and)Tj
1.7348 0 Td
(a)Tj
0.6519 0 Td
(proof)Tj
2.4095 0 Td
(of)Tj
1.0148 0 Td
(concept)Tj
3.3618 0 Td
(POCT.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 261.0141 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
/F11 1 Tf
0 -1.5023 Td
(Clinician)Tj
4.0394 0 Td
(survey)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 211.9748 225.9779 cm
BT
/F11 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Survey)Tj
3.033 0 Td
(respondents.)Tj
/F6 1 Tf
6.1568 0 Td
(45)Tj
1.1679 0 Td
(primary)Tj
3.4582 0 Td
(care)Tj
1.8709 0 Td
(clinicians)Tj
4.0081 0 Td
(completed)Tj
4.4051 0 Td
(the)Tj
1.4683 0 Td
(survey)Tj
2.8119 0 Td
(but)Tj
1.5534 0 Td
(not)Tj
1.5761 0 Td
(all)Tj
1.1452 0 Td
(respon-)Tj
-33.8511 -1.2982 Td
(dents)Tj
2.3754 0 Td
(completed)Tj
4.4106 0 Td
(all)Tj
1.1452 0 Td
(survey)Tj
2.812 0 Td
(questions.)Tj
4.2462 0 Td
(The)Tj
1.7859 0 Td
(majority)Tj
3.6283 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(respondents)Tj
5.108 0 Td
(\(21\))Tj
1.8482 0 Td
(were)Tj
2.126 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4683 0 Td
(UK,)Tj
-35.6425 -1.2983 Td
(and)Tj
1.7291 0 Td
(others)Tj
2.7099 0 Td
(from)Tj
2.2053 0 Td
(Belgium)Tj
3.549 0 Td
(\(9\),)Tj
1.5987 0 Td
(The)Tj
1.7858 0 Td
(Netherlands)Tj
5.1193 0 Td
(\(3\),)Tj
1.5988 0 Td
(Poland)Tj
3.0444 0 Td
(\(3\),)Tj
1.5987 0 Td
(Spain)Tj
2.4604 0 Td
(\(2\),)Tj
1.6044 0 Td
(USA)Tj
2.1147 0 Td
(\(2\),)Tj
1.6044 0 Td
(Germany)Tj
-32.7229 -1.3039 Td
(\(1\),)Tj
1.5987 0 Td
(Finland)Tj
3.3222 0 Td
(\(1\),)Tj
1.5987 0 Td
(Norway)Tj
3.4072 0 Td
(\(1\),)Tj
1.6044 0 Td
(Sweden)Tj
3.2995 0 Td
(\(1\))Tj
1.3776 0 Td
(and)Tj
1.7292 0 Td
(Australia)Tj
3.8437 0 Td
(\(1\).)Tj
1.6044 0 Td
(34)Tj
1.1679 0 Td
(\(70%\))Tj
2.6078 0 Td
(respondents)Tj
5.108 0 Td
(were)Tj
2.126 0 Td
(clini-)Tj
-34.3953 -1.2983 Td
(cally)Tj
2.0239 0 Td
(research)Tj
3.5546 0 Td
(active,)Tj
2.7496 0 Td
(and)Tj
1.7291 0 Td
(their)Tj
2.109 0 Td
(clinical)Tj
3.0727 0 Td
(workload)Tj
3.9968 0 Td
(relating)Tj
3.2712 0 Td
(to)Tj
1.0261 0 Td
(infections)Tj
4.1556 0 Td
(varied)Tj
2.6929 0 Td
(from)Tj
/F13 1 Tf
0 Tc
2.211 0 Td
(<)Tj
/F6 1 Tf
-0.004 Tc
(20%)Tj
2.6986 0 Td
(to)Tj
-35.2911 -1.2982 Td
(60%.)Tj
/F11 1 Tf
1.1962 -1.2983 Td
(Clinical)Tj
3.4752 0 Td
(priority)Tj
3.4696 0 Td
(for)Tj
1.474 0 Td
(POCT)Tj
2.9027 0 Td
(development.)Tj
/F6 1 Tf
6.4459 0 Td
(Community)Tj
5.125 0 Td
(acquired)Tj
3.702 0 Td
(pneumonia)Tj
4.8132 0 Td
(\(CAP\))Tj
2.8063 0 Td
(was)Tj
-35.4101 -1.3039 Td
(the)Tj
1.4683 0 Td
(LRTI)Tj
2.33 0 Td
(given)Tj
2.3811 0 Td
(the)Tj
1.4684 0 Td
(highest)Tj
3.0897 0 Td
(overall)Tj
2.9027 0 Td
(ranking)Tj
3.3505 0 Td
(with)Tj
2.0012 0 Td
(16)Tj
1.1679 0 Td
(\(35.6%\))Tj
3.3109 0 Td
(respondents)Tj
5.108 0 Td
(giving)Tj
2.6872 0 Td
(it)Tj
0.788 0 Td
(a)Tj
0.652 0 Td
(ranking)Tj
3.3505 0 Td
(of)Tj
1.0148 0 Td
(1)Tj
-37.0712 -1.2983 Td
(\(high)Tj
2.347 0 Td
(priority\))Tj
3.6113 0 Td
(and)Tj
1.7348 0 Td
(34)Tj
1.1679 0 Td
(\(75.6%\))Tj
3.3108 0 Td
(giving)Tj
2.6873 0 Td
(a)Tj
0.6519 0 Td
(ranking)Tj
3.3562 0 Td
(of)Tj
1.0148 0 Td
(between)Tj
3.5263 0 Td
(1)Tj
0.6973 0 Td
(and)Tj
1.7291 0 Td
(3.)Tj
0.9185 0 Td
(11)Tj
1.1735 0 Td
(\(24.4%\))Tj
3.3108 0 Td
(respondents)Tj
-31.2375 -1.2982 Td
(also)Tj
1.7687 0 Td
(selected)Tj
3.3449 0 Td
(influenza)Tj
3.9175 0 Td
(and)Tj
1.7291 0 Td
(acute)Tj
2.33 0 Td
(exacerbations)Tj
5.6806 0 Td
(of)Tj
1.0148 0 Td
(chronic)Tj
3.2882 0 Td
(obstructive)Tj
4.6601 0 Td
(airways)Tj
3.2258 0 Td
(disease)Tj
-30.9597 -1.304 Td
(\(aeCOPD\))Tj
4.4616 0 Td
(as)Tj
1.0148 0 Td
(their)Tj
2.109 0 Td
(highest)Tj
3.0897 0 Td
(priority.)Tj
3.498 0 Td
(Acute)Tj
2.5795 0 Td
(exacerbations)Tj
5.6806 0 Td
(of)Tj
1.0148 0 Td
(asthma)Tj
3.0954 0 Td
(and)Tj
1.7291 0 Td
(bronchitis)Tj
4.303 0 Td
(were)Tj
-32.5755 -1.2982 Td
(selected)Tj
3.3448 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(top)Tj
1.5477 0 Td
(priority)Tj
3.2712 0 Td
(by)Tj
1.1849 0 Td
(7)Tj
0.6916 0 Td
(\(15.6%\))Tj
3.3109 0 Td
(and)Tj
1.7291 0 Td
(4)Tj
0.6973 0 Td
(\(8.9%\))Tj
2.8346 0 Td
(respondents.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 201.9968 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Developing)Tj
5.1236 0 Td
(a)Tj
0.7654 0 Td
(target)Tj
2.7354 0 Td
(product)Tj
3.4938 0 Td
(profile)Tj
2.8913 0 Td
(for)Tj
1.3677 0 Td
(a)Tj
0.7654 0 Td
(commu)Tj
3.2315 0 Td
(nity-acqui)Tj
4.1953 0 Td
(red)Tj
1.6441 0 Td
(lower)Tj
2.5583 0 Td
(respiratory)Tj
4.8615 0 Td
(tract)Tj
2.1331 0 Td
(infection)Tj
3.8764 0 Td
(point)Tj
2.3386 0 Td
(of)Tj
1.0417 0 Td
(care)Tj
2.1331 0 Td
(test)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02005)Tj
4.089 0 Td
(31)Tj
0 g
2.0906 0 Td
(August)Tj
3.2882 0 Td
(1,)Tj
1.0418 0 Td
(2018)Tj
34.5758 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
87 0 obj
<>stream
endstream
endobj
88 0 obj
<>stream
endstream
endobj
89 0 obj
<>stream
endstream
endobj
90 0 obj
<>stream
endstream
endobj
91 0 obj
<>stream
endstream
endobj
92 0 obj
<>stream
endstream
endobj
93 0 obj
<>stream
BT
66.402 0 Td
(13)Tj
ET
Q
endstream
endobj
94 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 96 0 R/Contents 97 0 R/TrimBox[0 0 612 792]>>
endobj
95 0 obj
<>stream
xy[Up0g!QCJDRq,A3DRL0'&M)KĹ{E$q&b!)l{/wy{a?