Anthropogenic and environmental factors associated with high incidence of mcr-1 carriage in humans across China

Shen, Yingbo, Zhou, Hongwei, Xu, Jiao, Wang, Yongqiang, Zhang, Qijing, Walsh, Timothy R. ORCID: https://orcid.org/0000-0003-4315-4096, Shao, Bing, Wu, Congming, Hu, Yanyan, Yang, Lu, Shen, Zhangqi, Wu, Zuowei, Sun, Qiaoling, Ou, Yanran, Wang, Yueling, Wang, Shaolin, Wu, Yongning, Cai, Chang, Li, Juan, Shen, Jianzhong, Zhang, Rong and Wang, Yang 2018. Anthropogenic and environmental factors associated with high incidence of mcr-1 carriage in humans across China. Nature Microbiology 3 (9) , pp. 1054-1062. 10.1038/s41564-018-0205-8

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Abstract

MCR-1-positve Escherichia coli (MCRPEC) have been reported in humans worldwide; however, thus far, their prevalence is low and potential sources for human mcr-1 carriage have not yet been identified. Here, we analyse a nationwide epidemiological dataset on MCRPEC in humans throughout China and assess the factors associated with MCRPEC carriage using natural and national anthropogenic data. We identified 774 non-duplicate MCRPEC isolates from 774 stool samples collected from 5,159 healthy individuals in 30 provinces and municipalities in 2016, with a prevalence of MCRPEC ranging from 3.7 to 32.7% (average: 15.0%)—substantially higher than previously reported. MCRPEC carriage was associated with provincial regions, the production of sheep and freshwater aquaculture, annual consumption of total meat, pork and mutton, and daily intake of aquaculture products. MCRPEC was significantly more prevalent in provinces with higher aquaculture industries. Whole-genome sequencing analysis revealed that the MCRPEC isolates were clustered into four distinct lineages, two of which were dominant and harboured most of the MCRPEC isolates. The high prevalence of MCRPEC in the community poses a substantial risk for colistin usage in clinical practice and suggests the need for intestinal screening of mcr-1 carriers in intensive care units in Chinese hospitals. Furthermore, our data suggest that aquaculture is a significant reservoir of mcr-1.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Nature Publishing Group
ISSN:	2058-5276
Date of First Compliant Deposit:	6 September 2018
Date of Acceptance:	22 June 2018
Last Modified:	07 Nov 2023 18:28
URI:	https://orca.cardiff.ac.uk/id/eprint/114710

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