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Do defective immune system-mediated myelination processes increase postpartum psychosis risk?

Dazzan, Paola, Fusté, Montserrat and Davies, William 2018. Do defective immune system-mediated myelination processes increase postpartum psychosis risk? Trends in Molecular Medicine 24 (11) , pp. 942-949. 10.1016/j.molmed.2018.09.002

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Abstract

Postpartum (or puerperal) psychosis (PP) is a rare, severe psychiatric disorder that affects women shortly after childbirth; risk is particularly high in individuals with a history of bipolar disorder or PP, but the underlying pathophysiology remains poorly understood. Emerging evidence suggests that immune system (dys)function plays an important role in disorder onset. On the basis of new findings from clinical and animal model studies, we hypothesise that the abundance and/or activity of regulatory T cells, and the efficacy of consequent (re)myelination processes in the brain mediated by CCN proteins, is perturbed in PP; this pathway may be modulated by risk and protective/treatment factors for the disorder, and identifying abnormalities within it could signpost novel predictive biomarkers and therapeutic targets.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Psychology
Publisher: Elsevier
ISSN: 1471-4914
Funders: Medical Research Council; Medical Research Foundation; Psychiatry Research Trust; National Institute for Health Research Biomedical Research Centre at South London and Maudsley NHS Foundation Trust
Date of First Compliant Deposit: 17 September 2018
Date of Acceptance: 14 September 2018
Last Modified: 14 Mar 2019 16:41
URI: http://orca.cf.ac.uk/id/eprint/114958

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