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Protect us from poor-quality medical research

Ioannidis, John P.A, Bhattacharya, Siladitya, Evers, J.L.H., van der Veen, Fulco, Somigliana, Edgardo, Barratt, Christopher L.R., Bontempi, Gianluca, Baird, David T., Crosignani, PierGiorgio, Devroey, Paul, Diedrich, Klaus, Farquharson, Roy G., Fraser, Lynn R., Geraedts, Joep P.M., Gianaroli, Luca, La Vecchia, Carlo, Lundin, Kersti, Magli, Cristina, Negri, Eva, Sunde, Arne, Tapanainen, Juha S., Tarlatzis, Basil C., Van Steirteghem, Andre and Veiga, Anna 2018. Protect us from poor-quality medical research. Human Reproduction 33 (5) , pp. 770-776. 10.1093/humrep/dey056

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Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Oxford University Press
ISSN: 0268-1161
Date of Acceptance: 1 March 2018
Last Modified: 31 Jan 2020 03:55

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