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Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in the bile acid-farnesoid X receptor-fibroblast growth factor pathway

Monaghan, Tanya, Mullish, Benjamin H, Patterson, Jordan, Wong, Gane K S, Marchesi, Julian R., Xu, Huiping, Jilani, Tahseen and Kao, Dina 2019. Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in the bile acid-farnesoid X receptor-fibroblast growth factor pathway. Gut Microbes 10 (2) , pp. 142-148. 10.1080/19490976.2018.1506667

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Abstract

The mechanisms of efficacy for fecal microbiota transplantation (FMT) in treating recurrent Clostridioides difficile infection (rCDI) remain poorly defined, with restored gut microbiota-bile acid interactions representing one possible explanation. Furthermore, the potential implications for host physiology of these FMT-related changes in gut bile acid metabolism are also not well explored. In this study, we investigated the impact of FMT for rCDI upon signalling through the farnesoid X receptor (FXR)-fibroblast growth factor (FGF) pathway. Herein, we identify that in addition to restoration of gut microbiota and bile acid profiles, FMT for rCDI is accompanied by a significant, sustained increase in circulating levels of FGF19 and reduction in FGF21. These FGF changes were associated with weight gain post-FMT, to a level not exceeding the pre-rCDI baseline. Collectively, these data support the hypothesis that the restoration of gut microbial communities by FMT for rCDI is associated with an upregulated FXR-FGF pathway, and highlight the potential systemic effect of FMT.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Landes Bioscience
ISSN: 1949-0976
Date of First Compliant Deposit: 2 October 2018
Date of Acceptance: 25 July 2018
Last Modified: 03 Jun 2019 14:22
URI: http://orca.cf.ac.uk/id/eprint/115466

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