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Secukinumab for psoriatic arthritis: comparative effectiveness versus licensed biologics/apremilast: a network meta-analysis

McInnes, Iain B, Nash, Peter, Ritchlin, Christopher, Choy, Ernest H, Kanters, Steve, Thom, Howard, Gandhi, Kunal, Pricop, Luminita and Jugl, Steffen M 2018. Secukinumab for psoriatic arthritis: comparative effectiveness versus licensed biologics/apremilast: a network meta-analysis. Journal of Comparative Effectiveness Research 7 (11) , pp. 1107-1123. 10.2217/cer-2018-0075

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Abstract

Aim: A network meta-analysis using randomized controlled trial data compared psoriatic arthritis (PsA) outcomes (American College of Rheumatology [ACR], Psoriasis Area Severity Index [PASI] and Psoriatic Arthritis Response Criteria [PsARC] response rates) at 12–16 weeks for secukinumab, adalimumab, apremilast, certolizumab, etanercept, golimumab, infliximab and ustekinumab. Patients & methods: Trials were identified by systematic review. Separate networks were developed for the full-study populations, biologic-naive patients and biologic-experienced patients. Results: In the full populations, secukinumab, adalimumab, golimumab and infliximab demonstrated the highest ACR response rates. Secukinumab and infliximab demonstrated the highest PASI response rates, and infliximab and etanercept demonstrated the highest PsARC response rates. Conclusion: In the full populations, secukinumab demonstrated good efficacy across all outcomes. All treatments for active PsA included in this comprehensive network meta-analysis demonstrated superiority to placebo.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Future Medicine
ISSN: 2042-6305
Date of First Compliant Deposit: 5 October 2018
Date of Acceptance: 3 September 2018
Last Modified: 24 Jan 2019 13:56
URI: http://orca.cf.ac.uk/id/eprint/115565

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