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Gut microbiota, chemotherapy and the host: the influence of the gut microbiota on cancer treatment

Pouncey, Anna Louise, Scott, Alasdair James, Alexander, James Leslie, Marchesi, Julian and Kinross, James 2018. Gut microbiota, chemotherapy and the host: the influence of the gut microbiota on cancer treatment. ecancermedicalscience 12 , 868. 10.3332/ecancer.2018.868

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Abstract

The gut microbiota exists in a dynamic balance between symbiosis and pathogenesis and can influence almost any aspect of host physiology. Growing evidence suggests that the gut microbiota not only plays a key role in carcinogenesis but also influences the efficacy and toxicity of anticancer therapy. The microbiota modulates the host response to chemotherapy via numerous mechanisms, including immunomodulation, xenometabolism and alteration of community structure. Furthermore, exploitation of the microbiota offers opportunities for the personalisation of chemotherapeutic regimens and the development of novel therapies. In this article, we explore the host-chemotherapeutic microbiota axis, from basic science to clinical research, and describe how it may change the face of cancer treatment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Cancer Intelligence
ISSN: 1754-6605
Date of First Compliant Deposit: 12 October 2018
Date of Acceptance: 7 August 2018
Last Modified: 15 Oct 2018 12:45
URI: http://orca.cf.ac.uk/id/eprint/115796

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