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Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study

Kopczynska, Maja, Sharif, Ben, Cleaver, Sian, Spencer, Naomi, Kurani, Amit, Lee, Camilla, Davis, Jessica, Durie, Carys, Joseph-Gubral, Jude, Sharma, Angelica, Allen, Lucy, Atkins, Billi, Gordon, Alexandra, Jones, Llewelyn, Noble, Amy, Bradley, Matthew, Atkinson, Henry, Inns, Joy, Penney, Harriet, Gilbert, Carys, Walford, Rebecca, Pike, Louise, Edwards, Ross, Howcroft, Robyn, Preston, Hazel, Gee, Jennifer, Doyle, Nicholas, Maden, Charlotte, Smith, Claire, Nik Azis, Nik Syakira, Vadivale, Navrhinaa and Szakmany, Tamas 2018. Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study. BMC Research Notes 11 (1) , 720. 10.1186/s13104-018-3819-2

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Abstract

Objective Sepsis mortality is reported to be high worldwide, however recently the attributable fraction of mortality due to sepsis (AFsepsis) has been questioned. If improvements in treatment options are to be evaluated, it is important to know what proportion of deaths are potentially preventable or modifiable after a sepsis episode. The aim of the study was to establish the fraction of deaths directly related to the sepsis episode on the general wards and emergency departments. Results 839 patients were recruited over the two 24-h periods in 2016 and 2017. 521 patients fulfilled SEPSIS-3 criteria. 166 patients (32.4%) with sepsis and 56 patients (17.6%) without sepsis died within 90 days. Out of the 166 sepsis deaths 12 (7.2%) could have been directly related to sepsis, 28 (16.9%) possibly related and 96 (57.8%) were not related to sepsis. Overall AFsepsis was 24.1%. Upon analysis of the 40 deaths likely to be attributable to sepsis, we found that 31 patients (77.5%) had the Clinical Frailty Score ≥ 6, 28 (70%) had existing DNA-CPR order and 17 had limitations of care orders (42.5%).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: BioMed Central
ISSN: 1756-0500
Funders: Fiona Elizabeth Agnew Trust
Date of First Compliant Deposit: 12 October 2018
Date of Acceptance: 3 October 2018
Last Modified: 30 May 2019 21:36
URI: http://orca.cf.ac.uk/id/eprint/115850

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