Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Switching chemoselectivity: using mechanochemistry to alter reaction kinetics

Howard, Joseph L., Brand, Michael C. and Browne, Duncan L. ORCID: https://orcid.org/0000-0002-8604-229X 2018. Switching chemoselectivity: using mechanochemistry to alter reaction kinetics. Angewandte Chemie International Edition 57 (49) , pp. 16104-16108. 10.1002/anie.201810141

[thumbnail of Howard_et_al-2018-Angewandte_Chemie_International_Edition.pdf]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (4MB) | Preview

Abstract

A reaction manifold has been discovered in which the chemoselectivity can be altered by switching between neat milling and liquid assisted grinding (LAG) with polar additives. After investigation of the reaction mechanism, it has been established that this switching in reaction pathway is due to the neat mechanochemical conditions exhibiting different kinetics for a key step in the transformation. This proof of concept study demonstrates that mechanochemistry can be used to trap the kinetic product of a reaction. It is envisaged that, if this concept can be successfully applied to other transformations, novel synthetic processes could be discovered and known reaction pathways perturbed or diverted.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Wiley
ISSN: 1433-7851
Funders: EPSRC
Date of First Compliant Deposit: 19 October 2018
Date of Acceptance: 13 October 2018
Last Modified: 06 May 2023 07:20
URI: https://orca.cardiff.ac.uk/id/eprint/116005

Citation Data

Cited 54 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics