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The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on

Guidi, Luiz G., Velayos-Baeza, Antonio, Martinez Garay, Isabel, Monaco, Anthony P., Paracchini, Silvia, Bishop, Dorothy V. M. and Molnár, Zoltán 2018. The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on. European Journal of Neuroscience 48 (10) , pp. 3212-3233. 10.1111/ejn.14149

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Abstract

The capacity for language is one of the key features underlying the complexity of human cognition and its evolution. However, little is known about the neurobiological mechanisms that mediate normal or impaired linguistic ability. For developmental dyslexia, early postmortem studies conducted in the 1980s linked the disorder to subtle defects in the migration of neurons in the developing neocortex. These early studies were reinforced by human genetic analyses that identified dyslexia susceptibility genes and subsequent evidence of their involvement in neuronal migration. In this review, we examine recent experimental evidence that does not support the link between dyslexia and neuronal migration. We critically evaluate gene function studies conducted in rodent models and draw attention to the lack of robust evidence from histopathological and imaging studies in humans. Our review suggests that the neuronal migration hypothesis of dyslexia should be reconsidered, and the neurobiological basis of dyslexia should be approached with a fresh start.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Wiley
ISSN: 0953-816X
Date of First Compliant Deposit: 22 October 2018
Date of Acceptance: 13 August 2018
Last Modified: 17 Jan 2019 16:38
URI: http://orca.cf.ac.uk/id/eprint/116057

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