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Robust Buchwald-Hartwig amination enabled by ball-milling

Cao, Qun, Nicholson, William I., Jones, Andrew C. and Browne, Duncan L. 2019. Robust Buchwald-Hartwig amination enabled by ball-milling. Organic and Biomolecular Chemistry 17 (7) , pp. 1722-1726. 10.1039/C8OB01781F

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Abstract

An operationally simple mechanochemical method for the Pd catalysed Buchwald–Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system. The system is demonstrated on 30 substrates and applied in the context of a target synthesis. Furthermore, the performance of the reaction under aerobic conditions has been probed under traditional solution and mechanochemical conditions, the observations are discussed herein.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Royal Society of Chemistry
ISSN: 1477-0520
Funders: EPSRC
Date of First Compliant Deposit: 23 October 2018
Date of Acceptance: 3 September 2018
Last Modified: 21 Aug 2019 02:22
URI: http://orca.cf.ac.uk/id/eprint/116117

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