Cao, Qun, Nicholson, William I., Jones, Andrew C. and Browne, Duncan L.
2019.
Robust Buchwald-Hartwig amination enabled by ball-milling.
Organic and Biomolecular Chemistry
17
(7)
, pp. 1722-1726.
10.1039/C8OB01781F
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Official URL: http://dx.doi.org/10.1039/C8OB01781F
Abstract
An operationally simple mechanochemical method for the Pd catalysed Buchwald–Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system. The system is demonstrated on 30 substrates and applied in the context of a target synthesis. Furthermore, the performance of the reaction under aerobic conditions has been probed under traditional solution and mechanochemical conditions, the observations are discussed herein.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Publisher: | Royal Society of Chemistry |
ISSN: | 1477-0520 |
Funders: | EPSRC |
Date of First Compliant Deposit: | 23 October 2018 |
Date of Acceptance: | 3 September 2018 |
Last Modified: | 06 Jan 2021 02:35 |
URI: | http://orca.cf.ac.uk/id/eprint/116117 |
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