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Sarcoidosis following alemtuzumab treatment for multiple sclerosis

Willis, Mark D, Hope-Gill, Ben, Flood-Page, Patrick, Joseph, Fady, Needham, Ed, Jones, Joanne, Coles, Alasdair and Robertson, Neil P 2018. Sarcoidosis following alemtuzumab treatment for multiple sclerosis. Multiple Sclerosis 24 (13) , 1779-`782. 10.1177/1352458518790391

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Abstract

Despite proven efficacy of alemtuzumab in multiple sclerosis (MS), approximately 50% of individuals will develop a new autoimmune disease following treatment. To date, these have largely been antibody mediated and organ specific (primarily affecting the thyroid gland). In a retrospective case series of 187 patients from two UK specialist centres (Cardiff and Cambridge) followed up for a median of 10 years, we report three (1.6%) cases of sarcoidosis following alemtuzumab treatment of MS. This report increases the spectrum of auto-inflammatory disease following alemtuzumab and should be considered by clinicians when using this therapeutic agent for MS.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: SAGE Publications
ISSN: 1352-4585
Date of First Compliant Deposit: 25 October 2018
Date of Acceptance: 11 June 2018
Last Modified: 22 Jan 2019 15:03
URI: http://orca.cf.ac.uk/id/eprint/116174

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