Saladini, Francesco, Foley, Brian T., Rosi, Andrea, Vicenti, Ilaria, Nannetti, Giulio, Meini, Genny, Razzolini, Francesca and Zazzi, Maurizio
2012.
Near full-length sequence analysis of HIV Type 1 BF recombinants from Italy.
AIDS Research and Human Retroviruses
28
(3)
, p. 299.
10.1089/aid.2011.0002
|
Abstract
Recombination between HIV-1 subtypes B and F has generated several circulating and unique recombinant forms, particularly in Latin American areas. In Italy, subtype B is highly prevalent while subtype F is the most common pure non-B subtype. To investigate the recombination pattern in Italian BF recombinant viruses, we characterized full-length sequences derived from 15 adult patients, mostly Italian and infected by the heterosexual route. One of the BF mosaics was a CRF29, three sequences clustered with low bootstrap values with CRF39, CRF40, and CRF42. With the exception of the CRF29-like sequence, the other recombination patterns were unique, but two possible clusters were identified. Analysis of the gp120 V3 domain suggested a possible link with subtype F from Eastern Europe rather than from Latin America, favoring the hypothesis of local recombination between clade B and F viruses over that of import of BF recombinants from Latin America. HIV-1 subtypes B and F appear prone to generation of unique recombinants in Italy, warranting epidemiological surveillance and investigation of a possible clinical significance.
Item Type: |
Article
|
Date Type: |
Publication |
Status: |
Published |
Schools: |
Pharmacy |
Publisher: |
Mary Ann Liebert |
ISSN: |
0889-2229 |
Date of First Compliant Deposit: |
29 October 2018 |
Last Modified: |
27 Jun 2019 13:32 |
URI: |
http://orca.cf.ac.uk/id/eprint/116279 |
Citation Data
Cited 2 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
 |
Edit Item |