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Near full-length sequence analysis of HIV Type 1 BF recombinants from Italy

Saladini, Francesco, Foley, Brian T., Rosi, Andrea, Vicenti, Ilaria, Nannetti, Giulio, Meini, Genny, Razzolini, Francesca and Zazzi, Maurizio 2012. Near full-length sequence analysis of HIV Type 1 BF recombinants from Italy. AIDS Research and Human Retroviruses 28 (3) , p. 299. 10.1089/aid.2011.0002

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Recombination between HIV-1 subtypes B and F has generated several circulating and unique recombinant forms, particularly in Latin American areas. In Italy, subtype B is highly prevalent while subtype F is the most common pure non-B subtype. To investigate the recombination pattern in Italian BF recombinant viruses, we characterized full-length sequences derived from 15 adult patients, mostly Italian and infected by the heterosexual route. One of the BF mosaics was a CRF29, three sequences clustered with low bootstrap values with CRF39, CRF40, and CRF42. With the exception of the CRF29-like sequence, the other recombination patterns were unique, but two possible clusters were identified. Analysis of the gp120 V3 domain suggested a possible link with subtype F from Eastern Europe rather than from Latin America, favoring the hypothesis of local recombination between clade B and F viruses over that of import of BF recombinants from Latin America. HIV-1 subtypes B and F appear prone to generation of unique recombinants in Italy, warranting epidemiological surveillance and investigation of a possible clinical significance.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Publisher: Mary Ann Liebert
ISSN: 0889-2229
Date of First Compliant Deposit: 29 October 2018
Last Modified: 27 Jun 2019 13:32

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