Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Rituximab in neurological disease: principles, evidence and practice

Whittam, Daniel H, Tallantyre, Emma C, Jolles, Stephen, Huda, Saif, Moots, Robert J, Kim, Ho Jin, Robertson, Neil P, Cree, Bruce A C and Jacob, Anu 2019. Rituximab in neurological disease: principles, evidence and practice. Practical Neurology 19 (1) , pp. 5-10. 10.1136/practneurol-2018-001899

[img]
Preview
PDF - Accepted Post-Print Version
Download (1MB) | Preview

Abstract

Rituximab is a widely used B-cell-depleting monoclonal antibody. It is unlicensed for use in neurological disorders and there are no treatment guidelines. However, as a rapidly acting, targeted therapy with growing evidence of efficacy and tolerability in several neuroinflammatory disorders, it is an attractive alternative to conventional immunomodulatory medications. This practical review aims to explain the basic principles of B-cell depletion with therapeutic monoclonal antibodies. We present the evidence for using rituximab in neurological diseases, and describe the practical aspects of prescribing, including dosing, monitoring, safety, treatment failure and its use in special circumstances such as coexisting viral hepatitis, pregnancy and lactation. We provide an administration guide, checklist and patient information leaflet, which can be adapted for local use. Finally, we review the safety data of rituximab and ocrelizumab (a newer and recently licensed B-cell-depleting therapy for multiple sclerosis) and suggest monitoring and risk reduction strategies.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: BMJ Publishing Group / Blackwell Publishing
ISSN: 1474-7758
Date of First Compliant Deposit: 4 February 2019
Last Modified: 31 Mar 2019 23:21
URI: http://orca.cf.ac.uk/id/eprint/117275

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics