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DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation

Mansell, Els, Zareian, Nahid, Malouf, Camille, Kapeni, Chrysa, Brown, Natalie, Badie, Christophe, Baird, Duncan, Lane, Jon, Ottersbach, Katrin, Blair, Allison and Case, Charles Patrick 2019. DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation. Scientific Reports 9 , 4370. 10.1038/s41598-019-39552-0

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Abstract

For many diseases with a foetal origin, the cause for the disease initiation remains unknown. Common childhood acute leukaemia is thought to be caused by two hits, the first in utero and the second in childhood in response to infection. The mechanism for the initial DNA damaging event are unknown. Here we have used in vitro, ex vivo and in vivo models to show that a placental barrier will respond to agents that are suspected of initiating childhood leukaemia by releasing factors that cause DNA damage in cord blood and bone marrow cells, including stem cells. We show that DNA damage caused by in utero exposure can reappear postnatally after an immune challenge. Furthermore, both foetal and postnatal DNA damage are prevented by prenatal exposure of the placenta to a mitochondrially-targeted antioxidant. We conclude that the placenta might contribute to the first hit towards leukaemia initiation by bystander-like signalling to foetal haematopoietic cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Nature Publishing Group
ISSN: 2045-2322
Date of First Compliant Deposit: 5 December 2018
Date of Acceptance: 5 November 2018
Last Modified: 31 May 2019 08:50
URI: http://orca.cf.ac.uk/id/eprint/117395

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