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PPP1, a plant-specific regulator of transcription controls Arabidopsis development and PIN expression

Benjamins, René, Barbez, Elke, Ortbauer, Martina, Terpstra, Inez, Lucyshyn, Doris, Moulinier-Anzola, Jeanette, Khan, Muhammad Asaf, Leitner, Johannes, Malenica, Nenad, Butt, Haroon, Korbei, Barbara, Scheres, Ben, Kleine-Vehn, Jürgen and Luschnig, Christian 2016. PPP1, a plant-specific regulator of transcription controls Arabidopsis development and PIN expression. Scientific Reports 6 (1) , 32196. 10.1038/srep32196

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Abstract

Directional transport of auxin is essential for plant development, with PIN auxin transport proteins representing an integral part of the machinery that controls hormone distribution. However, unlike the rapidly emerging framework of molecular determinants regulating PIN protein abundance and subcellular localization, insights into mechanisms controlling PIN transcription are still limited. Here we describe PIN2 PROMOTER BINDING PROTEIN 1 (PPP1), an evolutionary conserved plant-specific DNA binding protein that acts on transcription of PIN genes. Consistent with PPP1 DNA-binding activity, PPP1 reporter proteins are nuclear localized and analysis of PPP1 null alleles and knockdown lines indicated a function as a positive regulator of PIN expression. Furthermore, we show that ppp1 pleiotropic mutant phenotypes are partially reverted by PIN overexpression, and results are presented that underline a role of PPP1-PIN promoter interaction in PIN expression control. Collectively, our findings identify an elementary, thus far unknown, plant-specific DNA-binding protein required for post-embryonic plant development, in general, and correct expression of PIN genes, in particular

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Nature Publishing Group
ISSN: 2045-2322
Date of First Compliant Deposit: 10 December 2018
Date of Acceptance: 4 August 2016
Last Modified: 12 Dec 2018 15:45
URI: http://orca.cf.ac.uk/id/eprint/117520

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