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Update on current approaches to diagnosis and treatment of onychomycosis

Gupta, Aditya K., Mays, Rachel R., Versteeg, Sarah G., Shear, Neil H. and Piguet, Vincent 2018. Update on current approaches to diagnosis and treatment of onychomycosis. Expert Review of Anti-infective Therapy 16 (12) , pp. 929-938. 10.1080/14787210.2018.1544891

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Abstract

Introduction: Onychomycosis is a chronic fungal infection of the nail bed, matrix or plate. It accounts for roughly 50% of all nail disease. As the prevalence of onychomycosis is increasing, a critical review of diagnostic techniques and treatment options is required. Areas covered: This review discusses the current diagnostic techniques associated with diagnosing onychomycosis, such as microscopy, culture, periodic acid Schiff stain (PAS) and polymerase chain reaction (PCR). Oral and topical therapies are also discussed, as well as, the utility of device-based treatments and combination therapy. Expert commentary: Culture for the diagnosis of onychomycosis is the gold standard; however, PCR is more sensitive and should be considered. In general, topical treatments are recommended for mild to moderate disease and oral treatments should be considered for moderate to severe disease. Combination therapy and device-based treatments may enhance cure rates, further study is required.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Expert Reviews
ISSN: 1478-7210
Date of Acceptance: 2 November 2018
Last Modified: 14 Dec 2018 14:45
URI: http://orca.cf.ac.uk/id/eprint/117669

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