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Unconventional T cell targets for cancer immunotherapy

Godfrey, Dale I., Le Nours, Jérôme, Andrews, Daniel M., Uldrich, Adam P. and Rossjohn, Jamie 2018. Unconventional T cell targets for cancer immunotherapy. Immunity 48 (3) , pp. 453-473. 10.1016/j.immuni.2018.03.009

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Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility complex (MHC) class I and MHC class II molecules, respectively. However, unconventional T cells, which interact with MHC class Ib and MHC-I like molecules, are also implicated in tumor immunity, although their role therein is unclear. These include unconventional T cells targeting MHC class Ib molecules such as HLA-E and its murine ortholog Qa-1b, natural killer T (NKT) cells, mucosal associated invariant T (MAIT) cells, and γδ T cells. Here, we review the current understanding of the roles of these unconventional T cells in tumor immunity and discuss why further studies into the immunotherapeutic potential of these cells is warranted

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier (Cell Press)
ISSN: 1074-7613
Date of First Compliant Deposit: 16 April 2019
Last Modified: 19 Oct 2019 16:59

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