Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Antiviral activity of bone morphogenetic proteins and activins

Eddowes, Lucy A., Al-Hourani, Kinda, Ramamurthy, Narayan, Frankish, Jamie, Baddock, Hannah T, Sandor, Cynthia, Ryan, John D., Fusco, Dahlene N., Arezes, João, Giannoulatou, Eleni, Boninsegna, Sara, Chevaliez, Stephane, Owens, Benjamin M. J., Sun, Chia Chi, Fabris, Paolo, Giordani, Maria Teresa, Martines, Diego, Vukicevic, Slobodan, Crowe, John, Lin, Herbert Y., Rehwinkel, Jan, McHugh, Peter J., Binder, Marco, Babitt, Jodie L., Chung, Raymond T., Lawless, Matthew W., Armitage, Andrew E., Webber, Caleb, Klenerman, Paul and Drakesmith, Hal 2018. Antiviral activity of bone morphogenetic proteins and activins. Nature Microbiology 4 , pp. 339-351. 10.1038/s41564-018-0301-9
Item availability restricted.

[img] PDF - Accepted Post-Print Version
Restricted to Repository staff only until 3 June 2019 due to copyright restrictions.

Download (14MB)

Abstract

Understanding the control of viral infections is of broad importance. Chronic hepatitis C virus (HCV) infection causes decreased expression of the iron hormone hepcidin, which is regulated by hepatic bone morphogenetic protein (BMP)/SMAD signalling. We found that HCV infection and the BMP/SMAD pathway are mutually antagonistic. HCV blunted induction of hepcidin expression by BMP6, probably via tumour necrosis factor (TNF)-mediated downregulation of the BMP co-receptor haemojuvelin. In HCV-infected patients, disruption of the BMP6/hepcidin axis and genetic variation associated with the BMP/SMAD pathway predicted the outcome of infection, suggesting that BMP/SMAD activity influences antiviral immunity. Correspondingly, BMP6 regulated a gene repertoire reminiscent of type I interferon (IFN) signalling, including upregulating interferon regulatory factors (IRFs) and downregulating an inhibitor of IFN signalling, USP18. Moreover, in BMP-stimulated cells, SMAD1 occupied loci across the genome, similar to those bound by IRF1 in IFN-stimulated cells. Functionally, BMP6 enhanced the transcriptional and antiviral response to IFN, but BMP6 and related activin proteins also potently blocked HCV replication independently of IFN. Furthermore, BMP6 and activin A suppressed growth of HBV in cell culture, and activin A inhibited Zika virus replication alone and in combination with IFN. The data establish an unappreciated important role for BMPs and activins in cellular antiviral immunity, which acts independently of, and modulates, IFN.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: Nature Publishing Group
ISSN: 2058-5276
Date of First Compliant Deposit: 2 January 2019
Date of Acceptance: 22 October 2018
Last Modified: 28 Feb 2019 22:23
URI: http://orca.cf.ac.uk/id/eprint/117953

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics