Wenzel, Margot N., Mósca, Andreia F., Graziani, Valentina, Aikman, Brech, Thomas, Sophie R., De Almeida, Andreia, Platts, James A., Re, Nazzareno, Coletti, Cecilia, Marrone, Alessandro, Soveral, Graça and Casini, Angela 2019. Insights into the mechanisms of aquaporin-3 inhibition by gold(III) complexes: the importance of non-coordinative adduct formation. Inorganic Chemistry 58 (3) , -. 10.1021/acs.inorgchem.8b03233 |
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Official URL: http://dx.doi.org/10.1021/acs.inorgchem.8b03233
Abstract
A series of six new Au(III) coordination compounds with phenanthroline ligands have been synthesized and studied for the inhibition of the water and glycerol channel aquaporin-3 (AQP3). From a combination of different experimental and computational approaches, further insights into the mechanisms of AQP3 inhibition by gold compounds at a molecular level have been gained. The results evidence the importance of noncoordinative adduct formation, prior to “covalent” protein binding, to achieve selective AQP3 inhibition.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry Advanced Research Computing @ Cardiff (ARCCA) |
Publisher: | American Chemical Society |
ISSN: | 0020-1669 |
Date of First Compliant Deposit: | 16 January 2019 |
Date of Acceptance: | 3 January 2019 |
Last Modified: | 11 Feb 2021 02:23 |
URI: | http://orca.cf.ac.uk/id/eprint/118439 |
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