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Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV)

Re:Viral Ltd 2016. Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV). WO2016055780A1. [Patent].

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Abstract

Benzimidazoles of formula (I): wherein: one of X and Y is an N atom or a substituted C atom, and the other is CH; L o is a single bond, C 1 alkylene, C2 alkenylene or C2 alkynylene; R1 is Ci alkyl, C2 alkenyl, C2 alkynyl, 3- to 10-membered cycloalkyl, 5- to 10-membered heterocyclyl or 5- to 12- membered heteroaryl, each of which is unsubstituted or substituted; Z is halo, C i haloalkyl, nitro, -CN, -N(R )2, -OR2, -SR2, -S(=0)R 2, or -S(=0) 2R2; each R2 is independently hydrogen, Ci_ alkyl, C2. alkenyl or o C2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; and m is 0 or 1; and the pharmaceutic ally acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

Item Type: Patent
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Subjects: R Medicine > R Medicine (General)
Last Modified: 24 Jan 2019 17:07
URI: http://orca.cf.ac.uk/id/eprint/118462

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