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Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p

Liu, Zihao, Zhou, You, Liang, Gehao, Ling, Yun, Tan, Weige, Tan, Luyuan, Andrews, Robert, Zhong, Wenjing, Zhang, Xuanxuan, Song, Erwei and Gong, Chang 2019. Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p. Cell Death and Disease 10 (2) , 55. 10.1038/s41419-018-1287-1

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Abstract

Increasing evidence suggests circular RNAs (circRNAs) exert critical functions in tumor progression via sponging miRNAs (microRNAs). However, the role of circRNAs in breast cancer remains unclear. Here we systematically analyzed the circular RNAs in breast cancer based on their characteristic in sponging disease-specific miRNAs and identified hsa_circ_001783 as a top ranked circRNA in our computation and verified its high expression in both breast cancer cells and cancer tissue. A higher level of hsa_circ_001783 was significantly correlated with heavier tumor burden and poorer prognosis of patients with breast cancer. Knockdown of this circRNA remarkably inhibited the proliferation and invasion of breast cancer cells. Importantly, hsa_circ_001783 promoted progression of breast cancer cells via sponging miR-200c-3p. Taken together, hsa_circ_001783 may serve as a novel prognostic and therapeutic target for breast cancer.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Data Innovation Research Institute (DIURI)
Medicine
Systems Immunity Research Institute (SIURI)
Publisher: Nature Publishing Group: Open Access Journals - Option B / Nature Publishing Group
ISSN: 2041-4889
Funders: CRUK&ARUK
Date of First Compliant Deposit: 28 January 2019
Date of Acceptance: 22 January 2019
Last Modified: 21 Feb 2019 11:30
URI: http://orca.cf.ac.uk/id/eprint/118877

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