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Short-term white matter alterations in alzheimer's disease characterized by diffusion tensor imaging

Genc, Sila, Steward, Christopher E., Malpas, Charles B., Velakoulis, Dennis, O'Brien, Terence J. and Desmond, Patricia M. 2016. Short-term white matter alterations in alzheimer's disease characterized by diffusion tensor imaging. Journal of Magnetic Resonance Imaging 43 (3) , pp. 627-634. 10.1002/jmri.25017

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Abstract

Purpose To investigate whether there are any white matter changes in a 6‐month follow‐up of mild‐moderate Alzheimer's patients using diffusion tensor imaging (DTI). Materials and Methods We recruited 18 mild‐moderate Alzheimer's disease patients and they underwent magnetic resonance imaging (MRI) at recruitment and at 6‐month follow‐up. Diffusion MRI images were processed using DTI‐ToolKit to create a population‐based tensor template. This template was integrated with a voxel‐wise and atlas‐based analysis in FSL to determine the magnitude and location of change in diffusion metrics over the 6‐month follow‐up period. Results There were significant widespread changes in diffusion metrics across the entire white matter skeleton (P < 0.001), 95% confidence interval (CI) difference in fractional anisotropy: −0.007 (−0.011, −0.002), mean diffusivity: 0.040 (0.023, 0.058), axial diffusivity: 0.015 (0.008, 0.022), radial diffusivity: 0.012 (0.006, 0.019), as well as regions of interest in the splenium and superior longitudinal fasciculus. Conclusion Our findings show that diffusion metrics are altered in a 6‐month follow‐up period of mild‐moderate Alzheimer's patients, supporting the potential of DTI metrics to act as sensitive biomarkers for disease progression even over a relatively short time interval, and the potential utility to be applied to clinical trials of putative disease‐modifying therapies. J. MAGN. RESON. IMAGING 2016;43:627–634.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher: Wiley
ISSN: 1053-1807
Date of Acceptance: 10 July 2015
Last Modified: 12 Apr 2019 10:45
URI: http://orca.cf.ac.uk/id/eprint/120646

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