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Cellular geography of IP3 receptors, STIM and Orai: a lesson from secretory epithelial cells

Dingsdale, Hayley, Voronina, Svetlana, Haynes, Lee, Tepikin, Alexei and Lur, Gyorgy 2012. Cellular geography of IP3 receptors, STIM and Orai: a lesson from secretory epithelial cells. Biochemical Society Transactions 40 (1) , pp. 108-111. 10.1042/BST20110639

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Abstract

Pancreatic acinar cells exhibit a remarkable polarization of Ca2+ release and Ca2+ influx mechanisms. In the present brief review, we discuss the localization of channels responsible for Ca2+ release [mainly IP3 (inositol 1,4,5-trisphosphate) receptors] and proteins responsible for SOCE (store-operated Ca2+ entry). We also place these Ca2+-transporting mechanisms on the map of cellular organelles in pancreatic acinar cells, and discuss the physiological implications of the cellular geography of Ca2+ signalling. Finally, we highlight some unresolved questions stemming from recent observations of co-localization and co-immunoprecipitation of IP3 receptors with Orai channels in the apical (secretory) region of pancreatic acinar cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Portland Press
ISSN: 0300-5127
Last Modified: 01 Apr 2019 14:30
URI: http://orca.cf.ac.uk/id/eprint/120670

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