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Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells

Dingsdale, Hayley, Okeke, Emmanuel, Awais, Muhammad, Haynes, Lee, Criddle, David N., Sutton, Robert and Tepikin, Alexei V. 2013. Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells. Biochemical Journal 451 (1) , pp. 25-32. 10.1042/BJ20121864

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Abstract

We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER–PM junctions formed near the leading edge of migrating cells (usually within 0.5 μm of polymerized actin and close to focal adhesions) and appeared suddenly without sliding from the interior of the cell. The long distance sliding and dissolution of ER–PM junctions accompanied the tail withdrawal.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Portland Press
ISSN: 0264-6021
Last Modified: 15 Apr 2019 11:15
URI: http://orca.cf.ac.uk/id/eprint/120672

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