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Enzymatically-oxidized phospholipids assume center-stage as essential regulators of innate immunity and cell death

O'Donnell, V, Aldrovandi, M, Murphy, R C and Kronke, G 2019. Enzymatically-oxidized phospholipids assume center-stage as essential regulators of innate immunity and cell death. Science Signaling 12 (574) , eaau2293. 10.1126/scisignal.aau2293

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Abstract

Enzymatically oxidized phospholipids (eoxPLs) are formed through regulated processes by which eicosanoids or prostaglandins are attached to phospholipids (PLs) in immune cells. These eoxPLs comprise structurally diverse families of biomolecules with potent bioactivities, and they have important immunoregulatory roles in both health and disease. The formation of oxPLs through enzymatic pathways and their signaling capabilities are emerging concepts. This paradigm is changing our understanding of eicosanoid, prostaglandin, and PL biology in health and disease. eoxPLs have roles in cellular events such as ferroptosis, apoptosis, and blood clotting and diseases such as arthritis, diabetes, and cardiovascular disease. They are increasingly recognized as endogenous bioactive mediators and potential targets for drug development. This review will describe recent evidence that places eoxPLs and their biosynthetic pathways center stage in immunoregulation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: American Association for the Advancement of Science
ISSN: 1945-0877
Date of First Compliant Deposit: 18 June 2019
Date of Acceptance: 8 March 2019
Last Modified: 27 Jun 2019 17:39
URI: http://orca.cf.ac.uk/id/eprint/120699

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