Directional gene flow and ecological separation in Yersinia enterocolitica

Reuter, Sandra, Thomson, Nicholas R., de Been, Mark, Hall, Miquette, Harris, Simon, McNally, Alan, Cheng, Lu ORCID: https://orcid.org/0000-0002-6391-2360 and Corander, Jukka 2015. Directional gene flow and ecological separation in Yersinia enterocolitica. Microbial Genomics 1 (3) , -. 10.1099/mgen.0.000030

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Abstract

Yersinia enterocolitica is a common cause of food-borne gastroenteritis worldwide. Recent work defining the phylogeny of the genus Yersinia subdivided Y. enterocolitica into six distinct phylogroups. Here, we provide detailed analyses of the evolutionary processes leading to the emergence of these phylogroups. The dominant phylogroups isolated from human infections, PG3–5, show very little diversity at the sequence level, but do present marked patterns of gain and loss of functions, including those involved in pathogenicity and metabolism, including the acquisition of phylogroup-specific O-antigen loci. We tracked gene flow across the species in the core and accessory genome, and show that the non-pathogenic PG1 strains act as a reservoir for diversity, frequently acting as donors in recombination events. Analysis of the core and accessory genome also suggested that the different Y. enterocolitica phylogroups may be ecologically separated, in contrast to the long-held belief of common shared ecological niches across the Y. enterocolitica species.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Biosciences
ISSN:	2057-5858
Date of Acceptance:	9 August 2015
Last Modified:	25 Oct 2022 13:46
URI:	https://orca.cardiff.ac.uk/id/eprint/120722

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