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The ryanodine receptor pore: Is there a consensus view?

Carney, Joanne, Mason, Sammy A., Viero, Cedric and Williams, Alan J. 2010. The ryanodine receptor pore: Is there a consensus view? In: Serysheva, Irina I. ed. Structure and Function of Calcium Release Channels, Vol. 66. Current Topics in Membranes, Elsevier Academic Press In, pp. 49-67. (10.1016/S1063-5823(10)66003-6)

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Abstract

The intracellular Ca2+-release channel referred to as the “ryanodine receptor (RyR)” is a key factor in a plethora of biological and pathophysiological processes. This chapter reviews a fundamental aspect of RyR function—the structures and mechanisms that controls ion flow through the open channel and underpins the unusual ion handling characteristics of RyR and its great efficiency as a Ca2+-release channel. The chapter focuses on a small region of the channel that provides the pathway for ion movement across the membrane: the pore-forming region (PFR). The likely structure of the pore-forming region (PFR) has been provided by high-resolution cryo-electron microscopy (cryo-EM) and by molecular modeling, following the identification of structural analogies between RyR and other ion channels. The mechanisms involved in discrimination and translocation have emerged from detailed characterization of channel function, theoretical models, and the interpretation of the consequences of residue mutation in the PFR. Together, these approaches have been used to identify regions of RyR that are critical for ion movement and may contribute to the binding site for ryanodine.

Item Type: Book Section
Date Type: Published Online
Status: Published
Schools: Centre for Trials Research (CNTRR)
Medicine
Publisher: Elsevier Academic Press In
ISBN: 9780123810373
Last Modified: 12 Jun 2019 02:28
URI: http://orca.cf.ac.uk/id/eprint/121345

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